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Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders
Notch signaling is a major pathway in cell fate decisions. Since the first reports showing the major role of Notch in embryonic development, a considerable and still growing literature further highlights its key contributions in various pathological processes during adult life. In particular, Notch...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645668/ https://www.ncbi.nlm.nih.gov/pubmed/23531541 http://dx.doi.org/10.3390/ijms14046863 |
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author | Quillard, Thibaut Charreau, Beatrice |
author_facet | Quillard, Thibaut Charreau, Beatrice |
author_sort | Quillard, Thibaut |
collection | PubMed |
description | Notch signaling is a major pathway in cell fate decisions. Since the first reports showing the major role of Notch in embryonic development, a considerable and still growing literature further highlights its key contributions in various pathological processes during adult life. In particular, Notch is now considered as a major player in vascular homeostasis through the control of key cellular functions. In parallel, confounding evidence emerged that inflammatory responses regulate Notch signaling in vitro in endothelial cells, smooth muscle cells or vascular infiltrating cells and in vivo in vascular and inflammatory disorders and in cardiovascular diseases. This review presents how inflammation influences Notch in vascular cells and, reciprocally, emphasizes the functional role of Notch on inflammatory processes, notably by regulating key cell functions (differentiation, proliferation, apoptosis/survival, activation). Understanding how the disparity of Notch receptors and ligands impacts on vasculature biology remains critical for the design of relevant and adequate therapeutic strategies targeting Notch in this major pathological context. |
format | Online Article Text |
id | pubmed-3645668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-36456682013-05-13 Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders Quillard, Thibaut Charreau, Beatrice Int J Mol Sci Review Notch signaling is a major pathway in cell fate decisions. Since the first reports showing the major role of Notch in embryonic development, a considerable and still growing literature further highlights its key contributions in various pathological processes during adult life. In particular, Notch is now considered as a major player in vascular homeostasis through the control of key cellular functions. In parallel, confounding evidence emerged that inflammatory responses regulate Notch signaling in vitro in endothelial cells, smooth muscle cells or vascular infiltrating cells and in vivo in vascular and inflammatory disorders and in cardiovascular diseases. This review presents how inflammation influences Notch in vascular cells and, reciprocally, emphasizes the functional role of Notch on inflammatory processes, notably by regulating key cell functions (differentiation, proliferation, apoptosis/survival, activation). Understanding how the disparity of Notch receptors and ligands impacts on vasculature biology remains critical for the design of relevant and adequate therapeutic strategies targeting Notch in this major pathological context. Molecular Diversity Preservation International (MDPI) 2013-03-26 /pmc/articles/PMC3645668/ /pubmed/23531541 http://dx.doi.org/10.3390/ijms14046863 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Quillard, Thibaut Charreau, Beatrice Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders |
title | Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders |
title_full | Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders |
title_fullStr | Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders |
title_full_unstemmed | Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders |
title_short | Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders |
title_sort | impact of notch signaling on inflammatory responses in cardiovascular disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645668/ https://www.ncbi.nlm.nih.gov/pubmed/23531541 http://dx.doi.org/10.3390/ijms14046863 |
work_keys_str_mv | AT quillardthibaut impactofnotchsignalingoninflammatoryresponsesincardiovasculardisorders AT charreaubeatrice impactofnotchsignalingoninflammatoryresponsesincardiovasculardisorders |