Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling

We explore the effects of the peripheral and transmembrane antimicrobial peptides on the lipid bilayer membrane by using the coarse grained Dissipative Particle Dynamics simulations. We study peptide/lipid membrane complexes by considering peptides with various structure, hydrophobicity and peptide/...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Licui, Jia, Nana, Gao, Lianghui, Fang, Weihai, Golubovic, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645725/
https://www.ncbi.nlm.nih.gov/pubmed/23579956
http://dx.doi.org/10.3390/ijms14047932
_version_ 1782268531900940288
author Chen, Licui
Jia, Nana
Gao, Lianghui
Fang, Weihai
Golubovic, Leonardo
author_facet Chen, Licui
Jia, Nana
Gao, Lianghui
Fang, Weihai
Golubovic, Leonardo
author_sort Chen, Licui
collection PubMed
description We explore the effects of the peripheral and transmembrane antimicrobial peptides on the lipid bilayer membrane by using the coarse grained Dissipative Particle Dynamics simulations. We study peptide/lipid membrane complexes by considering peptides with various structure, hydrophobicity and peptide/lipid interaction strength. The role of lipid/water interaction is also discussed. We discuss a rich variety of membrane morphological changes induced by peptides, such as pore formation, membrane corrugation and Euler buckling.
format Online
Article
Text
id pubmed-3645725
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-36457252013-05-13 Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling Chen, Licui Jia, Nana Gao, Lianghui Fang, Weihai Golubovic, Leonardo Int J Mol Sci Article We explore the effects of the peripheral and transmembrane antimicrobial peptides on the lipid bilayer membrane by using the coarse grained Dissipative Particle Dynamics simulations. We study peptide/lipid membrane complexes by considering peptides with various structure, hydrophobicity and peptide/lipid interaction strength. The role of lipid/water interaction is also discussed. We discuss a rich variety of membrane morphological changes induced by peptides, such as pore formation, membrane corrugation and Euler buckling. Molecular Diversity Preservation International (MDPI) 2013-04-11 /pmc/articles/PMC3645725/ /pubmed/23579956 http://dx.doi.org/10.3390/ijms14047932 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chen, Licui
Jia, Nana
Gao, Lianghui
Fang, Weihai
Golubovic, Leonardo
Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling
title Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling
title_full Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling
title_fullStr Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling
title_full_unstemmed Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling
title_short Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling
title_sort effects of antimicrobial peptide revealed by simulations: translocation, pore formation, membrane corrugation and euler buckling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645725/
https://www.ncbi.nlm.nih.gov/pubmed/23579956
http://dx.doi.org/10.3390/ijms14047932
work_keys_str_mv AT chenlicui effectsofantimicrobialpeptiderevealedbysimulationstranslocationporeformationmembranecorrugationandeulerbuckling
AT jianana effectsofantimicrobialpeptiderevealedbysimulationstranslocationporeformationmembranecorrugationandeulerbuckling
AT gaolianghui effectsofantimicrobialpeptiderevealedbysimulationstranslocationporeformationmembranecorrugationandeulerbuckling
AT fangweihai effectsofantimicrobialpeptiderevealedbysimulationstranslocationporeformationmembranecorrugationandeulerbuckling
AT golubovicleonardo effectsofantimicrobialpeptiderevealedbysimulationstranslocationporeformationmembranecorrugationandeulerbuckling

Ejemplares similares