Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis

We explored the contribution of nitrosamine metabolism to lung cancer in a pilot investigation of genetic variation in CYP2B6, a high-affinity enzymatic activator of tobacco-specific nitrosamines with a negligible role in nicotine metabolism. Previously we found that variation in CYP2A6 and CHRNA5-C...

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Detalles Bibliográficos
Autores principales: Wassenaar, Catherine A., Dong, Qiong, Amos, Christopher I., Spitz, Margaret R., Tyndale, Rachel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645749/
https://www.ncbi.nlm.nih.gov/pubmed/23591849
http://dx.doi.org/10.3390/ijms14048381

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