HIF proteins connect the RB-E2F factors to angiogenesis

Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF.(1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulati...

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Detalles Bibliográficos
Autores principales: Bakker, Walbert. J., Weijts, Bart G.M.W., Westendorp, Bart, de Bruin, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646055/
https://www.ncbi.nlm.nih.gov/pubmed/23412359
http://dx.doi.org/10.4161/trns.23680
Descripción
Sumario:Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF.(1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.

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