HIF proteins connect the RB-E2F factors to angiogenesis

Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF.(1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulati...

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Detalles Bibliográficos
Autores principales: Bakker, Walbert. J., Weijts, Bart G.M.W., Westendorp, Bart, de Bruin, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646055/
https://www.ncbi.nlm.nih.gov/pubmed/23412359
http://dx.doi.org/10.4161/trns.23680
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author Bakker, Walbert. J.
Weijts, Bart G.M.W.
Westendorp, Bart
de Bruin, Alain
author_facet Bakker, Walbert. J.
Weijts, Bart G.M.W.
Westendorp, Bart
de Bruin, Alain
author_sort Bakker, Walbert. J.
collection PubMed
description Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF.(1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.
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spelling pubmed-36460552013-06-03 HIF proteins connect the RB-E2F factors to angiogenesis Bakker, Walbert. J. Weijts, Bart G.M.W. Westendorp, Bart de Bruin, Alain Transcription Point of View Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF.(1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development. Landes Bioscience 2013-03-01 2013-02-14 /pmc/articles/PMC3646055/ /pubmed/23412359 http://dx.doi.org/10.4161/trns.23680 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Point of View
Bakker, Walbert. J.
Weijts, Bart G.M.W.
Westendorp, Bart
de Bruin, Alain
HIF proteins connect the RB-E2F factors to angiogenesis
title HIF proteins connect the RB-E2F factors to angiogenesis
title_full HIF proteins connect the RB-E2F factors to angiogenesis
title_fullStr HIF proteins connect the RB-E2F factors to angiogenesis
title_full_unstemmed HIF proteins connect the RB-E2F factors to angiogenesis
title_short HIF proteins connect the RB-E2F factors to angiogenesis
title_sort hif proteins connect the rb-e2f factors to angiogenesis
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646055/
https://www.ncbi.nlm.nih.gov/pubmed/23412359
http://dx.doi.org/10.4161/trns.23680
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AT weijtsbartgmw hifproteinsconnecttherbe2ffactorstoangiogenesis
AT westendorpbart hifproteinsconnecttherbe2ffactorstoangiogenesis
AT debruinalain hifproteinsconnecttherbe2ffactorstoangiogenesis

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