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Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis

Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century...

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Autores principales: Choi, Yun-Hee, Fujikawa, Teppei, Lee, Jiwon, Reuter, Anne, Kim, Ki Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646253/
https://www.ncbi.nlm.nih.gov/pubmed/23675313
http://dx.doi.org/10.3389/fnins.2013.00071
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author Choi, Yun-Hee
Fujikawa, Teppei
Lee, Jiwon
Reuter, Anne
Kim, Ki Woo
author_facet Choi, Yun-Hee
Fujikawa, Teppei
Lee, Jiwon
Reuter, Anne
Kim, Ki Woo
author_sort Choi, Yun-Hee
collection PubMed
description Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century, the ventral medial nucleus of the hypothalamus (VMH) was the first site reported to play a prominent role in the regulation of energy homeostasis through control of food intake and energy expenditure. Recent studies using sophisticated genetic tools have further highlighted the importance of the VMH and have extended our understanding of the physiological role of the nucleus in regulation of energy homeostasis. These genetic studies were preceded by the identification of steroidogenic factor-1 (SF-1) as a marker of the VMH. This review focuses on the emerging homeostatic roles of the SF-1 neurons in the VMH discovered through the use of genetic models, particularly highlighting the control of energy, and glucose homeostasis.
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spelling pubmed-36462532013-05-14 Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis Choi, Yun-Hee Fujikawa, Teppei Lee, Jiwon Reuter, Anne Kim, Ki Woo Front Neurosci Neuroscience Obesity, diabetes, and other metabolic complications are growing concerns for public health and could lead to detrimental life-threatening conditions. Neurons whose activities are required for energy and glucose homeostasis are found in a number of hypothalamic nuclei. In the early twentieth century, the ventral medial nucleus of the hypothalamus (VMH) was the first site reported to play a prominent role in the regulation of energy homeostasis through control of food intake and energy expenditure. Recent studies using sophisticated genetic tools have further highlighted the importance of the VMH and have extended our understanding of the physiological role of the nucleus in regulation of energy homeostasis. These genetic studies were preceded by the identification of steroidogenic factor-1 (SF-1) as a marker of the VMH. This review focuses on the emerging homeostatic roles of the SF-1 neurons in the VMH discovered through the use of genetic models, particularly highlighting the control of energy, and glucose homeostasis. Frontiers Media S.A. 2013-05-07 /pmc/articles/PMC3646253/ /pubmed/23675313 http://dx.doi.org/10.3389/fnins.2013.00071 Text en Copyright © 2013 Choi, Fujikawa, Lee, Reuter and Kim. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Choi, Yun-Hee
Fujikawa, Teppei
Lee, Jiwon
Reuter, Anne
Kim, Ki Woo
Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis
title Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis
title_full Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis
title_fullStr Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis
title_full_unstemmed Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis
title_short Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis
title_sort revisiting the ventral medial nucleus of the hypothalamus: the roles of sf-1 neurons in energy homeostasis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646253/
https://www.ncbi.nlm.nih.gov/pubmed/23675313
http://dx.doi.org/10.3389/fnins.2013.00071
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