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Breast cancer brain metastases: new directions in systemic therapy
The management of patients with brain metastases from breast cancer continues to be a major clinical challenge. The standard initial therapeutic approach depends upon the size, location, and number of metastatic lesions and includes consideration of surgical resection, whole-brain radiotherapy, and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cancer Intelligence
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646423/ https://www.ncbi.nlm.nih.gov/pubmed/23662165 http://dx.doi.org/10.3332/ecancer.2013.307 |
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author | Lin, Nancy U |
author_facet | Lin, Nancy U |
author_sort | Lin, Nancy U |
collection | PubMed |
description | The management of patients with brain metastases from breast cancer continues to be a major clinical challenge. The standard initial therapeutic approach depends upon the size, location, and number of metastatic lesions and includes consideration of surgical resection, whole-brain radiotherapy, and stereotactic radiosurgery. As systemic therapies for control of extracranial disease improve, patients are surviving long enough to experience subsequent progression events in the brain. Therefore, there is an increasing need to identify both more effective initial treatments as well as to develop multiple lines of salvage treatments for patients with breast cancer brain metastases. This review summarises the clinical experience to date with respect to cytotoxic and targeted systemic therapies for the treatment of brain metastases, highlights ongoing and planned trials of novel approaches and identifies potential targets for future investigation. |
format | Online Article Text |
id | pubmed-3646423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Cancer Intelligence |
record_format | MEDLINE/PubMed |
spelling | pubmed-36464232013-05-09 Breast cancer brain metastases: new directions in systemic therapy Lin, Nancy U Ecancermedicalscience Review The management of patients with brain metastases from breast cancer continues to be a major clinical challenge. The standard initial therapeutic approach depends upon the size, location, and number of metastatic lesions and includes consideration of surgical resection, whole-brain radiotherapy, and stereotactic radiosurgery. As systemic therapies for control of extracranial disease improve, patients are surviving long enough to experience subsequent progression events in the brain. Therefore, there is an increasing need to identify both more effective initial treatments as well as to develop multiple lines of salvage treatments for patients with breast cancer brain metastases. This review summarises the clinical experience to date with respect to cytotoxic and targeted systemic therapies for the treatment of brain metastases, highlights ongoing and planned trials of novel approaches and identifies potential targets for future investigation. Cancer Intelligence 2013-04-18 /pmc/articles/PMC3646423/ /pubmed/23662165 http://dx.doi.org/10.3332/ecancer.2013.307 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lin, Nancy U Breast cancer brain metastases: new directions in systemic therapy |
title | Breast cancer brain metastases: new directions in systemic therapy |
title_full | Breast cancer brain metastases: new directions in systemic therapy |
title_fullStr | Breast cancer brain metastases: new directions in systemic therapy |
title_full_unstemmed | Breast cancer brain metastases: new directions in systemic therapy |
title_short | Breast cancer brain metastases: new directions in systemic therapy |
title_sort | breast cancer brain metastases: new directions in systemic therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646423/ https://www.ncbi.nlm.nih.gov/pubmed/23662165 http://dx.doi.org/10.3332/ecancer.2013.307 |
work_keys_str_mv | AT linnancyu breastcancerbrainmetastasesnewdirectionsinsystemictherapy |