B-Raf and the inhibitors: from bench to bedside

The B-Raf protein is a key signaling molecule in the mitogen activated protein kinase (MAPK) signaling pathway and has been implicated in the pathogenesis of a variety of cancers. An important V600E mutation has been identified and can cause constitutive B-Raf activation. Recent studies have evaluat...

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Detalles Bibliográficos
Autores principales: Huang, Tiangui, Karsy, Michael, Zhuge, Jian, Zhong, Minghao, Liu, Delong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646677/
https://www.ncbi.nlm.nih.gov/pubmed/23617957
http://dx.doi.org/10.1186/1756-8722-6-30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646677/
https://www.ncbi.nlm.nih.gov/pubmed/23617957
http://dx.doi.org/10.1186/1756-8722-6-30

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