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Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats

Sleep is regulated by humoral and homeostatic processes. If on one hand chronic elevation of stress hormones impair sleep, on the other hand, rapid eye movement (REM) sleep deprivation induces elevation of glucocorticoids and time of REM sleep during the recovery period. In the present study we soug...

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Autores principales: Machado, Ricardo Borges, Tufik, Sergio, Suchecki, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646744/
https://www.ncbi.nlm.nih.gov/pubmed/23667630
http://dx.doi.org/10.1371/journal.pone.0063520
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author Machado, Ricardo Borges
Tufik, Sergio
Suchecki, Deborah
author_facet Machado, Ricardo Borges
Tufik, Sergio
Suchecki, Deborah
author_sort Machado, Ricardo Borges
collection PubMed
description Sleep is regulated by humoral and homeostatic processes. If on one hand chronic elevation of stress hormones impair sleep, on the other hand, rapid eye movement (REM) sleep deprivation induces elevation of glucocorticoids and time of REM sleep during the recovery period. In the present study we sought to examine whether manipulations of corticosterone levels during REM sleep deprivation would alter the subsequent sleep rebound. Adult male Wistar rats were fit with electrodes for sleep monitoring and submitted to four days of REM sleep deprivation under repeated corticosterone or metyrapone (an inhibitor of corticosterone synthesis) administration. Sleep parameters were continuously recorded throughout the sleep deprivation period and during 3 days of sleep recovery. Plasma levels of adrenocorticotropic hormone and corticosterone were also evaluated. Metyrapone treatment prevented the elevation of corticosterone plasma levels induced by REM sleep deprivation, whereas corticosterone administration to REM sleep-deprived rats resulted in lower corticosterone levels than in non-sleep deprived rats. Nonetheless, both corticosterone and metyrapone administration led to several alterations on sleep homeostasis, including reductions in the amount of non-REM and REM sleep during the recovery period, although corticosterone increased delta activity (1.0–4.0 Hz) during REM sleep deprivation. Metyrapone treatment of REM sleep-deprived rats reduced the number of REM sleep episodes. In conclusion, reduction of corticosterone levels during REM sleep deprivation resulted in impairment of sleep rebound, suggesting that physiological elevation of corticosterone levels resulting from REM sleep deprivation is necessary for plentiful recovery of sleep after this stressful event.
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spelling pubmed-36467442013-05-10 Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats Machado, Ricardo Borges Tufik, Sergio Suchecki, Deborah PLoS One Research Article Sleep is regulated by humoral and homeostatic processes. If on one hand chronic elevation of stress hormones impair sleep, on the other hand, rapid eye movement (REM) sleep deprivation induces elevation of glucocorticoids and time of REM sleep during the recovery period. In the present study we sought to examine whether manipulations of corticosterone levels during REM sleep deprivation would alter the subsequent sleep rebound. Adult male Wistar rats were fit with electrodes for sleep monitoring and submitted to four days of REM sleep deprivation under repeated corticosterone or metyrapone (an inhibitor of corticosterone synthesis) administration. Sleep parameters were continuously recorded throughout the sleep deprivation period and during 3 days of sleep recovery. Plasma levels of adrenocorticotropic hormone and corticosterone were also evaluated. Metyrapone treatment prevented the elevation of corticosterone plasma levels induced by REM sleep deprivation, whereas corticosterone administration to REM sleep-deprived rats resulted in lower corticosterone levels than in non-sleep deprived rats. Nonetheless, both corticosterone and metyrapone administration led to several alterations on sleep homeostasis, including reductions in the amount of non-REM and REM sleep during the recovery period, although corticosterone increased delta activity (1.0–4.0 Hz) during REM sleep deprivation. Metyrapone treatment of REM sleep-deprived rats reduced the number of REM sleep episodes. In conclusion, reduction of corticosterone levels during REM sleep deprivation resulted in impairment of sleep rebound, suggesting that physiological elevation of corticosterone levels resulting from REM sleep deprivation is necessary for plentiful recovery of sleep after this stressful event. Public Library of Science 2013-05-07 /pmc/articles/PMC3646744/ /pubmed/23667630 http://dx.doi.org/10.1371/journal.pone.0063520 Text en © 2013 Machado et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Machado, Ricardo Borges
Tufik, Sergio
Suchecki, Deborah
Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats
title Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats
title_full Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats
title_fullStr Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats
title_full_unstemmed Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats
title_short Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats
title_sort role of corticosterone on sleep homeostasis induced by rem sleep deprivation in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646744/
https://www.ncbi.nlm.nih.gov/pubmed/23667630
http://dx.doi.org/10.1371/journal.pone.0063520
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