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FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

Sphingosine-1-phosphate (S1P) is a pluripotent lipophilic mediator working as a ligand for G-protein coupled S1P receptors (S1PR), which is currently highlighted as a therapeutic target for autoimmune diseases including relapsing forms of multiple sclerosis. Sphingosine related compounds, FTY720 and...

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Detalles Bibliográficos
Autores principales:	Takasugi, Nobumasa, Sasaki, Tomoki, Ebinuma, Ihori, Osawa, Satoko, Isshiki, Hayato, Takeo, Koji, Tomita, Taisuke, Iwatsubo, Takeshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646787/ https://www.ncbi.nlm.nih.gov/pubmed/23667698 http://dx.doi.org/10.1371/journal.pone.0064050

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