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Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population
Keloid is benign fibroproliferative dermal tumors with unknown etiology. Recently, a genome-wide association study (GWAS) in Japanese population has identified 3 susceptibility loci (rs873549 at 1q41, rs940187 and rs1511412 at 3q22.3, rs8032158 at 15p21.3) for keloid. In order to examine whether the...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646817/ https://www.ncbi.nlm.nih.gov/pubmed/23667473 http://dx.doi.org/10.1371/journal.pone.0062377 |
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author | Zhu, Fei Wu, Baoyu Li, Ping Wang, Jianbo Tang, Huayang Liu, Ye Zuo, Xianbo Cheng, Hui Ding, Yantao Wang, Wen Zhai, Yujuan Qian, Fangfang Wang, Wenju Yuan, Xiangfeng Wang, Jing Ha, Weiwei Hou, Junsheng Zhou, Fusheng Wang, Yin Gao, Jinping Sheng, Yujun Sun, Liangdan Liu, Jianjun Yang, Sen Zhang, Xuejun |
author_facet | Zhu, Fei Wu, Baoyu Li, Ping Wang, Jianbo Tang, Huayang Liu, Ye Zuo, Xianbo Cheng, Hui Ding, Yantao Wang, Wen Zhai, Yujuan Qian, Fangfang Wang, Wenju Yuan, Xiangfeng Wang, Jing Ha, Weiwei Hou, Junsheng Zhou, Fusheng Wang, Yin Gao, Jinping Sheng, Yujun Sun, Liangdan Liu, Jianjun Yang, Sen Zhang, Xuejun |
author_sort | Zhu, Fei |
collection | PubMed |
description | Keloid is benign fibroproliferative dermal tumors with unknown etiology. Recently, a genome-wide association study (GWAS) in Japanese population has identified 3 susceptibility loci (rs873549 at 1q41, rs940187 and rs1511412 at 3q22.3, rs8032158 at 15p21.3) for keloid. In order to examine whether these susceptibility loci are associated with keloid in the Chinese Han population, twelve previously reported SNPs were selected for replication in 714 cases and 2,944 controls by using Sequenom MassArray system. We found three SNPs in two regions showed significant association with keloid in the Chinese Han population: 1q41 (rs873549, P = 3.03×10(−33), OR = 2.05, 95% CI: 1.82–2.31 and rs1442440, P = 9.85×10(−18), OR = 0.56, 95% CI: 0.49–0.64, respectively) and 15q21.3 (rs2271289 located in NEDD4, P = 1.02×10(−11), OR = 0.66, 95% CI: 0.58–0.74). We also detected one risk haplotype AG (P = 1.36×10(−31), OR = 2.02) and two protective haplotypes of GA and AA (GA, P = 1.94×10(−19), OR = 0.53, AA, P = 0.00043, OR = 0.78, respectively) from the two SNPs (rs873549 and rs1442440). Our study confirmed two previously reported loci 1q41 and 15q21.3 for keloid in the Chinese Han population, which suggested the common genetic factor predisposing to the development of keloid shared by the Chinese Han and Japanese populations. |
format | Online Article Text |
id | pubmed-3646817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36468172013-05-10 Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population Zhu, Fei Wu, Baoyu Li, Ping Wang, Jianbo Tang, Huayang Liu, Ye Zuo, Xianbo Cheng, Hui Ding, Yantao Wang, Wen Zhai, Yujuan Qian, Fangfang Wang, Wenju Yuan, Xiangfeng Wang, Jing Ha, Weiwei Hou, Junsheng Zhou, Fusheng Wang, Yin Gao, Jinping Sheng, Yujun Sun, Liangdan Liu, Jianjun Yang, Sen Zhang, Xuejun PLoS One Research Article Keloid is benign fibroproliferative dermal tumors with unknown etiology. Recently, a genome-wide association study (GWAS) in Japanese population has identified 3 susceptibility loci (rs873549 at 1q41, rs940187 and rs1511412 at 3q22.3, rs8032158 at 15p21.3) for keloid. In order to examine whether these susceptibility loci are associated with keloid in the Chinese Han population, twelve previously reported SNPs were selected for replication in 714 cases and 2,944 controls by using Sequenom MassArray system. We found three SNPs in two regions showed significant association with keloid in the Chinese Han population: 1q41 (rs873549, P = 3.03×10(−33), OR = 2.05, 95% CI: 1.82–2.31 and rs1442440, P = 9.85×10(−18), OR = 0.56, 95% CI: 0.49–0.64, respectively) and 15q21.3 (rs2271289 located in NEDD4, P = 1.02×10(−11), OR = 0.66, 95% CI: 0.58–0.74). We also detected one risk haplotype AG (P = 1.36×10(−31), OR = 2.02) and two protective haplotypes of GA and AA (GA, P = 1.94×10(−19), OR = 0.53, AA, P = 0.00043, OR = 0.78, respectively) from the two SNPs (rs873549 and rs1442440). Our study confirmed two previously reported loci 1q41 and 15q21.3 for keloid in the Chinese Han population, which suggested the common genetic factor predisposing to the development of keloid shared by the Chinese Han and Japanese populations. Public Library of Science 2013-05-07 /pmc/articles/PMC3646817/ /pubmed/23667473 http://dx.doi.org/10.1371/journal.pone.0062377 Text en © 2013 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhu, Fei Wu, Baoyu Li, Ping Wang, Jianbo Tang, Huayang Liu, Ye Zuo, Xianbo Cheng, Hui Ding, Yantao Wang, Wen Zhai, Yujuan Qian, Fangfang Wang, Wenju Yuan, Xiangfeng Wang, Jing Ha, Weiwei Hou, Junsheng Zhou, Fusheng Wang, Yin Gao, Jinping Sheng, Yujun Sun, Liangdan Liu, Jianjun Yang, Sen Zhang, Xuejun Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population |
title | Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population |
title_full | Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population |
title_fullStr | Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population |
title_full_unstemmed | Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population |
title_short | Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population |
title_sort | association study confirmed susceptibility loci with keloid in the chinese han population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646817/ https://www.ncbi.nlm.nih.gov/pubmed/23667473 http://dx.doi.org/10.1371/journal.pone.0062377 |
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