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Early Chk1 Phosphorylation Is Driven by Temozolomide-Induced, DNA Double Strand Break- and Mismatch Repair-Independent DNA Damage

Temozolomide (TMZ) is a DNA methylating agent used to treat brain cancer. TMZ-induced O6-methylguanine adducts, in the absence of repair by O6-methylguanine DNA methyltransferase (MGMT), mispair during DNA replication and trigger cycles of futile mismatch repair (MMR). Futile MMR in turn leads to th...

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Detalles Bibliográficos
Autores principales:	Ito, Motokazu, Ohba, Shigeo, Gaensler, Karin, Ronen, Sabrina M., Mukherjee, Joydeep, Pieper, Russell O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646831/ https://www.ncbi.nlm.nih.gov/pubmed/23667469 http://dx.doi.org/10.1371/journal.pone.0062351

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