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Selective Role of Mevalonate Pathway in Regulating Perforin but Not FasL and TNFalpha Release in Human Natural Killer Cells

We have analyzed the effects of fluvastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase involved in mevalonate synthesis, on human NK cell-mediated anti-tumor cytolysis. Fluvastatin inhibited the activation of the small guanosin triphosphate binding protein...

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Detalles Bibliográficos
Autores principales:	Poggi, Alessandro, Boero, Silvia, Musso, Alessandra, Zocchi, Maria Raffaella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646988/ https://www.ncbi.nlm.nih.gov/pubmed/23667543 http://dx.doi.org/10.1371/journal.pone.0062932

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