The Efficacy of Lapatinib in Metastatic Breast Cancer with HER2 Non-Amplified Primary Tumors and EGFR Positive Circulating Tumor Cells: A Proof-Of-Concept Study

BACKGROUND: Analysis of circulating tumor cells (CTCs) provides real-time measures of cancer sub-populations with potential for CTC-directed therapeutics. We examined whether lapatinib which binds both HER2 and EGFR could induce depletion of the EGFR-positive pool of CTCs, which may in turn lead to...

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Detalles Bibliográficos
Autores principales: Stebbing, Justin, Payne, Rachel, Reise, Justine, Frampton, Adam E., Avery, Miranda, Woodley, Laura, Di Leo, Angelo, Pestrin, Marta, Krell, Jonathan, Coombes, R. Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647066/
https://www.ncbi.nlm.nih.gov/pubmed/23667487
http://dx.doi.org/10.1371/journal.pone.0062543

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