A Highly Productive, Whole-Cell DERA Chemoenzymatic Process for Production of Key Lactonized Side-Chain Intermediates in Statin Synthesis

Employing DERA (2-deoxyribose-5-phosphate aldolase), we developed the first whole-cell biotransformation process for production of chiral lactol intermediates useful for synthesis of optically pure super-statins such as rosuvastatin and pitavastatin. Herein, we report the development of a fed-batch,...

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Detalles Bibliográficos
Autores principales: Ošlaj, Matej, Cluzeau, Jérôme, Orkić, Damir, Kopitar, Gregor, Mrak, Peter, Časar, Zdenko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647077/
https://www.ncbi.nlm.nih.gov/pubmed/23667462
http://dx.doi.org/10.1371/journal.pone.0062250

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