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Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma

BACKGROUND: BCL9 enhances β-catenin-mediated transcriptional activity regardless of the mutational status of the Wnt signaling components and increases the cell proliferation, migration, invasion, and metastatic potential of tumor cells. The goal of this study was to elucidate the prognostic signifi...

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Autores principales: Hyeon, Jiyeon, Ahn, Soomin, Lee, Jae Jun, Song, Dae Hyun, Park, Cheol-Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and The Korean Society for Cytopathology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647125/
https://www.ncbi.nlm.nih.gov/pubmed/23667372
http://dx.doi.org/10.4132/KoreanJPathol.2013.47.2.130
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author Hyeon, Jiyeon
Ahn, Soomin
Lee, Jae Jun
Song, Dae Hyun
Park, Cheol-Keun
author_facet Hyeon, Jiyeon
Ahn, Soomin
Lee, Jae Jun
Song, Dae Hyun
Park, Cheol-Keun
author_sort Hyeon, Jiyeon
collection PubMed
description BACKGROUND: BCL9 enhances β-catenin-mediated transcriptional activity regardless of the mutational status of the Wnt signaling components and increases the cell proliferation, migration, invasion, and metastatic potential of tumor cells. The goal of this study was to elucidate the prognostic significance of BCL9 protein expression in hepatocellular carcinoma (HCC) patients. METHODS: We evaluated BCL9 protein expression by immunohistochemistry in tumor tissue from 288 primary HCC patients who underwent curative hepatectomy. The impact of BCL9 expression on the survival of the patients was analyzed. The median follow-up period was 97.1 months. RESULTS: Nuclear BCL9 protein expression was observed in 74 (25.7%) of the 288 HCCs. BCL9 expression was significantly associated with younger age (p=0.038), higher Edmondson grade (p=0.001), microvascular invasion (p=0.013), and intrahepatic metastasis (p=0.017). Based on univariate analyses, BCL9 expression showed an unfavorable influence on both disease-free survival (DFS, p=0.012) and disease-specific survival (DSS, p=0.032). Multivariate analyses revealed that higher Barcelona Clinic Liver Cancer stage was an independent predictor of both shorter DFS (p<0.001) and shorter DSS (p<0.001). BCL9 expression tended to be an independent predictor of shorter DFS (p=0.078). CONCLUSIONS: BCL9 protein expression might be a marker of shorter DFS in HCC patients after curative hepatectomy.
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spelling pubmed-36471252013-05-10 Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma Hyeon, Jiyeon Ahn, Soomin Lee, Jae Jun Song, Dae Hyun Park, Cheol-Keun Korean J Pathol Original Article BACKGROUND: BCL9 enhances β-catenin-mediated transcriptional activity regardless of the mutational status of the Wnt signaling components and increases the cell proliferation, migration, invasion, and metastatic potential of tumor cells. The goal of this study was to elucidate the prognostic significance of BCL9 protein expression in hepatocellular carcinoma (HCC) patients. METHODS: We evaluated BCL9 protein expression by immunohistochemistry in tumor tissue from 288 primary HCC patients who underwent curative hepatectomy. The impact of BCL9 expression on the survival of the patients was analyzed. The median follow-up period was 97.1 months. RESULTS: Nuclear BCL9 protein expression was observed in 74 (25.7%) of the 288 HCCs. BCL9 expression was significantly associated with younger age (p=0.038), higher Edmondson grade (p=0.001), microvascular invasion (p=0.013), and intrahepatic metastasis (p=0.017). Based on univariate analyses, BCL9 expression showed an unfavorable influence on both disease-free survival (DFS, p=0.012) and disease-specific survival (DSS, p=0.032). Multivariate analyses revealed that higher Barcelona Clinic Liver Cancer stage was an independent predictor of both shorter DFS (p<0.001) and shorter DSS (p<0.001). BCL9 expression tended to be an independent predictor of shorter DFS (p=0.078). CONCLUSIONS: BCL9 protein expression might be a marker of shorter DFS in HCC patients after curative hepatectomy. The Korean Society of Pathologists and The Korean Society for Cytopathology 2013-04 2013-04-24 /pmc/articles/PMC3647125/ /pubmed/23667372 http://dx.doi.org/10.4132/KoreanJPathol.2013.47.2.130 Text en © 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hyeon, Jiyeon
Ahn, Soomin
Lee, Jae Jun
Song, Dae Hyun
Park, Cheol-Keun
Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma
title Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma
title_full Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma
title_fullStr Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma
title_full_unstemmed Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma
title_short Prognostic Significance of BCL9 Expression in Hepatocellular Carcinoma
title_sort prognostic significance of bcl9 expression in hepatocellular carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647125/
https://www.ncbi.nlm.nih.gov/pubmed/23667372
http://dx.doi.org/10.4132/KoreanJPathol.2013.47.2.130
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