Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis

AIM: To develop a C. elegans model of amyotrophic lateral sclerosis (ALS) and to evaluate the role of autophagy in the disease. METHODS: Stable transgenic worms expressing the G93A mutant form of Cu,Zn-superoxide dismutase (SOD1) in GABAergic motor neurons were generated. Axon guidance and protein a...

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Detalles Bibliográficos
Autores principales: Li, Jia, Huang, Kai-xing, Le, Wei-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647213/
https://www.ncbi.nlm.nih.gov/pubmed/23503474
http://dx.doi.org/10.1038/aps.2012.190

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