Therapeutic induction of autophagy to modulate neurodegenerative disease progression

There is accumulating evidence that aggregating, misfolded proteins may have an impact on autophagic function, suggesting that this could be a secondary pathological mechanism in many diseases. In this review, we focus on the role of autophagy in four major neurodegenerative diseases: Alzheimer dise...

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Detalles Bibliográficos
Autores principales: Hochfeld, Warren E, Lee, Shirley, Rubinsztein, David C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647215/
https://www.ncbi.nlm.nih.gov/pubmed/23377551
http://dx.doi.org/10.1038/aps.2012.189
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author Hochfeld, Warren E
Lee, Shirley
Rubinsztein, David C
author_facet Hochfeld, Warren E
Lee, Shirley
Rubinsztein, David C
author_sort Hochfeld, Warren E
collection PubMed
description There is accumulating evidence that aggregating, misfolded proteins may have an impact on autophagic function, suggesting that this could be a secondary pathological mechanism in many diseases. In this review, we focus on the role of autophagy in four major neurodegenerative diseases: Alzheimer disease (AD), Huntington's disease (HD), Parkinson's disease (PD) and amyotropic lateral sclerosis.
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spelling pubmed-36472152013-05-10 Therapeutic induction of autophagy to modulate neurodegenerative disease progression Hochfeld, Warren E Lee, Shirley Rubinsztein, David C Acta Pharmacol Sin Perspective There is accumulating evidence that aggregating, misfolded proteins may have an impact on autophagic function, suggesting that this could be a secondary pathological mechanism in many diseases. In this review, we focus on the role of autophagy in four major neurodegenerative diseases: Alzheimer disease (AD), Huntington's disease (HD), Parkinson's disease (PD) and amyotropic lateral sclerosis. Nature Publishing Group 2013-05 2013-02-04 /pmc/articles/PMC3647215/ /pubmed/23377551 http://dx.doi.org/10.1038/aps.2012.189 Text en Copyright © 2013 CPS and SIMM http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Perspective
Hochfeld, Warren E
Lee, Shirley
Rubinsztein, David C
Therapeutic induction of autophagy to modulate neurodegenerative disease progression
title Therapeutic induction of autophagy to modulate neurodegenerative disease progression
title_full Therapeutic induction of autophagy to modulate neurodegenerative disease progression
title_fullStr Therapeutic induction of autophagy to modulate neurodegenerative disease progression
title_full_unstemmed Therapeutic induction of autophagy to modulate neurodegenerative disease progression
title_short Therapeutic induction of autophagy to modulate neurodegenerative disease progression
title_sort therapeutic induction of autophagy to modulate neurodegenerative disease progression
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647215/
https://www.ncbi.nlm.nih.gov/pubmed/23377551
http://dx.doi.org/10.1038/aps.2012.189
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