Cargando…

Nuclear Transport Modulation Reduces Hypercholesterolemia, Atherosclerosis, and Fatty Liver

BACKGROUND: Elevated cholesterol and triglycerides in blood lead to atherosclerosis and fatty liver, contributing to rising cardiovascular and hepatobiliary morbidity and mortality worldwide. METHODS AND RESULTS: A cell‐penetrating nuclear transport modifier (NTM) reduced hyperlipidemia, atheroscler...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yan, Major, Amy S., Zienkiewicz, Jozef, Gabriel, Curtis L., Veach, Ruth Ann, Moore, Daniel J., Collins, Robert D., Hawiger, Jacek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647260/ https://www.ncbi.nlm.nih.gov/pubmed/23563994 http://dx.doi.org/10.1161/JAHA.113.000093

Ejemplares similares

Lethality in a Murine Model of Pulmonary Anthrax is Reduced by Combining Nuclear Transport Modifier with Antimicrobial Therapy
por: Veach, Ruth Ann, et al.
Publicado: (2012)

The “Genomic Storm” Induced by Bacterial Endotoxin Is Calmed by a Nuclear Transport Modifier That Attenuates Localized and Systemic Inflammation
por: DiGiandomenico, Antonio, et al.
Publicado: (2014)

Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles
por: Veach, Ruth Ann, et al.
Publicado: (2017)

In Vivo Islet Protection by a Nuclear Import Inhibitor in a Mouse Model of Type 1 Diabetes
por: Moore, Daniel J., et al.
Publicado: (2010)

Targeting Nuclear Import Shuttles, Importins/Karyopherins alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization Sequence
por: Zienkiewicz, Jozef, et al.
Publicado: (2013)

Genomic control of inflammation in experimental atopic dermatitis
por: Liu, Yan, et al.
Publicado: (2022)

Activation of thousands of genes in the lungs and kidneys by sepsis is countered by the selective nuclear blockade
por: Qiao, Huan, et al.
Publicado: (2023)

Hyperlipidemic hypersensitivity to lethal microbial inflammation and its reversal by selective targeting of nuclear transport shuttles
por: Liu, Yan, et al.
Publicado: (2021)

Decoding inflammation, its causes, genomic responses, and emerging countermeasures
por: Hawiger, Jacek, et al.
Publicado: (2019)

Protection from Endotoxin Shock by Selective Targeting of Proinflammatory Signaling to the Nucleus Mediated by Importin Alpha 5
por: Liu, Yan, et al.
Publicado: (2019)

New paradigms in sepsis: from prevention to protection of failing microcirculation
por: Hawiger, J., et al.
Publicado: (2015)

Insulin-like growth factor 1 reduces coronary atherosclerosis in pigs with familial hypercholesterolemia
por: Sukhanov, Sergiy, et al.
Publicado: (2023)

Greater preclinical atherosclerosis in treated monogenic familial hypercholesterolemia vs. polygenic hypercholesterolemia
por: Sharifi, Mahtab, et al.
Publicado: (2017)

Correlating corneal arcus with atherosclerosis in familial hypercholesterolemia
por: Zech, Loren A, et al.
Publicado: (2008)

Familial hypercholesterolemia supravalvular aortic stenosis and extensive atherosclerosis
por: Prajapati, Rajpal, et al.
Publicado: (2018)

Effects of castration on atherosclerosis in Yucatan minipigs with genetic hypercholesterolemia
por: Shim, Jeong T., et al.
Publicado: (2020)

EGF receptor–mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling
por: Chiusa, Manuel, et al.
Publicado: (2020)

Intermittent Fasting Inhibits High-Fat Diet–Induced Atherosclerosis by Ameliorating Hypercholesterolemia and Reducing Monocyte Chemoattraction
por: Chen, Yuanli, et al.
Publicado: (2021)

The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (II): - Contribution to the Development and Validation of the Therapeutics for Hypercholesterolemia and Atherosclerosis -
por: Shiomi, Masashi
Publicado: (2020)

Hypercholesterolemia Tunes Hematopoietic Stem/Progenitor Cells for Inflammation and Atherosclerosis
por: Ma, Xiaojuan, et al.
Publicado: (2016)

Atherosclerosis severity in patients with familial hypercholesterolemia: The role of T and B lymphocytes
por: Fonzar, Waleria T., et al.
Publicado: (2022)

Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia
por: Karpale, Mikko, et al.
Publicado: (2022)

Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs
por: Davis, Bryan T., et al.
Publicado: (2014)

Porcine Models of Accelerated Coronary Atherosclerosis: Role of Diabetes Mellitus and Hypercholesterolemia
por: Hamamdzic, Damir, et al.
Publicado: (2013)

SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia
por: Liu, Ming-Ming, et al.
Publicado: (2022)

Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients with Familial Hypercholesterolemia: The ARCHITECT Study
por: Pérez de Isla, Leopoldo, et al.
Publicado: (2023)

Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis
por: Sozen, Erdi, et al.
Publicado: (2014)

PDGFRβ signaling regulates local inflammation and synergizes with hypercholesterolemia to promote atherosclerosis
por: He, Chaoyong, et al.
Publicado: (2015)

PCSK9 immunization using nanoliposomes: preventive efficacy against hypercholesterolemia and atherosclerosis
por: Momtazi-Borojeni, Amir Abbas, et al.
Publicado: (2021)

Early Onset Intrauterine Growth Restriction in a Mouse Model of Gestational Hypercholesterolemia and Atherosclerosis
por: Busso, Dolores, et al.
Publicado: (2014)

Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia
por: Miyajima, Chiharu, et al.
Publicado: (2018)

Bitter Melon (Momordica charantia L.) Supplementation Has No Effect on Hypercholesterolemia and Atherosclerosis in Mice
por: Mohammadmoradi, Shayan, et al.
Publicado: (2020)

“Apple does not fall far from the tree” – subclinical atherosclerosis in children with familial hypercholesterolemia
por: Podgórski, Michał, et al.
Publicado: (2020)

Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia
por: Xu, Yitong, et al.
Publicado: (2022)

Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia
por: Liang, Chenxi, et al.
Publicado: (2022)

Subclinical atherosclerosis determined by coronary artery calcium deposition in patients with clinical familial hypercholesterolemia
por: Borg, Sanna á, et al.
Publicado: (2022)

Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
por: Granado-Serrano, A. B., et al.
Publicado: (2019)

Factors Associated with Carotid Atherosclerosis and Achilles Tendon Thickness in Japanese Patients with Familial Hypercholesterolemia: A Subanalysis of the Familial Hypercholesterolemia Expert Forum (FAME) Study
por: Ogura, Masatsune, et al.
Publicado: (2022)

Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice
por: Wang, Shu-Huei, et al.
Publicado: (2023)

Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of Atherosclerosis
por: Kassim, Sadik H., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_021eilnoiloeitcgeg9624mudv