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ROS‐Mediated PARP Activity Undermines Mitochondrial Function After Permeability Transition Pore Opening During Myocardial Ischemia–Reperfusion

BACKGROUND: Ischemia–reperfusion (I/R) studies have implicated oxidant stress, the mitochondrial permeability transition pore (mPTP), and poly(ADP‐ribose) polymerase (PARP) as contributing factors in myocardial cell death. However, the interdependence of these factors in the intact, blood‐perfused h...

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Detalles Bibliográficos
Autores principales:	Schriewer, Jacqueline M., Peek, Clara Bien, Bass, Joseph, Schumacker, Paul T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647275/ https://www.ncbi.nlm.nih.gov/pubmed/23598272 http://dx.doi.org/10.1161/JAHA.113.000159

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