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Ross Procedure in Children: 17‐Year Experience at a Single Institution

BACKGROUND: The Ross procedure in children carries substantial mortality and reoperation rate. Aortic root dilatation is of concern. To prevent dilatation of the neoaortic root, but permit normal growth, we began to apply an absorbable poly‐(p‐dioxanone)‐filaments (PDS) band at the sino‐tubular (ST)...

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Autores principales: Tan Tanny, Sharman P., Yong, Matthew S., d'Udekem, Yves, Kowalski, Remi, Wheaton, Gavin, D'Orsogna, Luigi, Galati, John C., Brizard, Christian P., Konstantinov, Igor E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647280/
https://www.ncbi.nlm.nih.gov/pubmed/23603736
http://dx.doi.org/10.1161/JAHA.113.000153
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author Tan Tanny, Sharman P.
Yong, Matthew S.
d'Udekem, Yves
Kowalski, Remi
Wheaton, Gavin
D'Orsogna, Luigi
Galati, John C.
Brizard, Christian P.
Konstantinov, Igor E.
author_facet Tan Tanny, Sharman P.
Yong, Matthew S.
d'Udekem, Yves
Kowalski, Remi
Wheaton, Gavin
D'Orsogna, Luigi
Galati, John C.
Brizard, Christian P.
Konstantinov, Igor E.
author_sort Tan Tanny, Sharman P.
collection PubMed
description BACKGROUND: The Ross procedure in children carries substantial mortality and reoperation rate. Aortic root dilatation is of concern. To prevent dilatation of the neoaortic root, but permit normal growth, we began to apply an absorbable poly‐(p‐dioxanone)‐filaments (PDS) band at the sino‐tubular (ST)‐junction. METHODS AND RESULTS: All children (n=100) who underwent Ross procedure during 1995–2012 were studied. Mean age at operation was 8.6±6.1 years (median 8.3 years, range 3 days to 18 years); 19 patients were younger than 1 year of age. The root replacement (n=91, Ross‐Konno procedure in 29 patients), root inclusion (n=6), and subcoronary implantation (n=3) techniques were used. Operative mortality was 6% (6/100, 4 neonates, 2 infants). Age of <1‐year at time of operation was a risk factor for early death (P<0.001). Mean follow‐up time was 7.0±4.8 years (median 7.4 years, range 5 days to 16 years). Late mortality was 4.3% (4/94). Freedom from moderate or greater neoaortic valve insufficiency (AI) at 5 and 10 years was 89% and 83%, respectively. Freedom from neoaortic valve reoperation at 5 and 10 years was 96% and 86%, respectively. Aortic dilatation to Z‐score >4 was greatest at the ST‐junction (23%, 11/48) compared to the aortic annulus (17%, 11/66) and sinuses (14%, 7/50). Since 2001, a PDS band was placed around the ST‐junction in 19 patients. Survivors with the PDS band had less AI (0 versus 20%, P=0.043) compared to survivors (n=35) without the PDS at 4.1±3 years. CONCLUSIONS: The Ross procedure in children can be performed with acceptable results. Children younger than 1 year of age have higher mortality, but not an increased autograft reoperation rate. Stabilization of the ST‐junction may reduce AI.
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spelling pubmed-36472802013-05-08 Ross Procedure in Children: 17‐Year Experience at a Single Institution Tan Tanny, Sharman P. Yong, Matthew S. d'Udekem, Yves Kowalski, Remi Wheaton, Gavin D'Orsogna, Luigi Galati, John C. Brizard, Christian P. Konstantinov, Igor E. J Am Heart Assoc Original Research BACKGROUND: The Ross procedure in children carries substantial mortality and reoperation rate. Aortic root dilatation is of concern. To prevent dilatation of the neoaortic root, but permit normal growth, we began to apply an absorbable poly‐(p‐dioxanone)‐filaments (PDS) band at the sino‐tubular (ST)‐junction. METHODS AND RESULTS: All children (n=100) who underwent Ross procedure during 1995–2012 were studied. Mean age at operation was 8.6±6.1 years (median 8.3 years, range 3 days to 18 years); 19 patients were younger than 1 year of age. The root replacement (n=91, Ross‐Konno procedure in 29 patients), root inclusion (n=6), and subcoronary implantation (n=3) techniques were used. Operative mortality was 6% (6/100, 4 neonates, 2 infants). Age of <1‐year at time of operation was a risk factor for early death (P<0.001). Mean follow‐up time was 7.0±4.8 years (median 7.4 years, range 5 days to 16 years). Late mortality was 4.3% (4/94). Freedom from moderate or greater neoaortic valve insufficiency (AI) at 5 and 10 years was 89% and 83%, respectively. Freedom from neoaortic valve reoperation at 5 and 10 years was 96% and 86%, respectively. Aortic dilatation to Z‐score >4 was greatest at the ST‐junction (23%, 11/48) compared to the aortic annulus (17%, 11/66) and sinuses (14%, 7/50). Since 2001, a PDS band was placed around the ST‐junction in 19 patients. Survivors with the PDS band had less AI (0 versus 20%, P=0.043) compared to survivors (n=35) without the PDS at 4.1±3 years. CONCLUSIONS: The Ross procedure in children can be performed with acceptable results. Children younger than 1 year of age have higher mortality, but not an increased autograft reoperation rate. Stabilization of the ST‐junction may reduce AI. Blackwell Publishing Ltd 2013-04-24 /pmc/articles/PMC3647280/ /pubmed/23603736 http://dx.doi.org/10.1161/JAHA.113.000153 Text en © 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell. http://creativecommons.org/licenses/by/2.5/ This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Tan Tanny, Sharman P.
Yong, Matthew S.
d'Udekem, Yves
Kowalski, Remi
Wheaton, Gavin
D'Orsogna, Luigi
Galati, John C.
Brizard, Christian P.
Konstantinov, Igor E.
Ross Procedure in Children: 17‐Year Experience at a Single Institution
title Ross Procedure in Children: 17‐Year Experience at a Single Institution
title_full Ross Procedure in Children: 17‐Year Experience at a Single Institution
title_fullStr Ross Procedure in Children: 17‐Year Experience at a Single Institution
title_full_unstemmed Ross Procedure in Children: 17‐Year Experience at a Single Institution
title_short Ross Procedure in Children: 17‐Year Experience at a Single Institution
title_sort ross procedure in children: 17‐year experience at a single institution
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647280/
https://www.ncbi.nlm.nih.gov/pubmed/23603736
http://dx.doi.org/10.1161/JAHA.113.000153
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