Mechanical Unloading Activates FoxO3 to Trigger Bnip3‐Dependent Cardiomyocyte Atrophy

BACKGROUND: Mechanical assist device therapy has emerged recently as an important and rapidly expanding therapy in advanced heart failure, triggering in some patients a beneficial reverse remodeling response. However, mechanisms underlying this benefit are unclear. METHODS AND RESULTS: In a model of...

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Detalles Bibliográficos
Autores principales: Cao, Dian J., Jiang, Nan, Blagg, Andrew, Johnstone, Janet L., Gondalia, Raj, Oh, Misook, Luo, Xiang, Yang, Kai‐Chun, Shelton, John M., Rothermel, Beverly A., Gillette, Thomas G., Dorn, Gerald W., Hill, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647287/
https://www.ncbi.nlm.nih.gov/pubmed/23568341
http://dx.doi.org/10.1161/JAHA.113.000016

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