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Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil

Pneumonia is most problematic for children in developing countries. In 2010, Brazil introduced a 10-valent pneumococcal conjugate vaccine (PCV10) to its National Immunization Program. To assess the vaccine’s effectiveness for preventing pneumonia, we analyzed rates of hospitalization among children...

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Autores principales: Afonso, Eliane Terezinha, Minamisava, Ruth, Bierrenbach, Ana Luiza, Escalante, Juan Jose Cortez, Alencar, Airlane Pereira, Domingues, Carla Magda, Morais-Neto, Otaliba Libanio, Toscano, Cristiana Maria, Andrade, Ana Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647414/
https://www.ncbi.nlm.nih.gov/pubmed/23628462
http://dx.doi.org/10.3201/eid1904.121198
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author Afonso, Eliane Terezinha
Minamisava, Ruth
Bierrenbach, Ana Luiza
Escalante, Juan Jose Cortez
Alencar, Airlane Pereira
Domingues, Carla Magda
Morais-Neto, Otaliba Libanio
Toscano, Cristiana Maria
Andrade, Ana Lucia
author_facet Afonso, Eliane Terezinha
Minamisava, Ruth
Bierrenbach, Ana Luiza
Escalante, Juan Jose Cortez
Alencar, Airlane Pereira
Domingues, Carla Magda
Morais-Neto, Otaliba Libanio
Toscano, Cristiana Maria
Andrade, Ana Lucia
author_sort Afonso, Eliane Terezinha
collection PubMed
description Pneumonia is most problematic for children in developing countries. In 2010, Brazil introduced a 10-valent pneumococcal conjugate vaccine (PCV10) to its National Immunization Program. To assess the vaccine’s effectiveness for preventing pneumonia, we analyzed rates of hospitalization among children 2–24 months of age who had pneumonia from all causes from January 2005 through August 2011. We used data from the National Hospitalization Information System to conduct an interrupted time-series analysis for 5 cities in Brazil that had good data quality and high PCV10 vaccination coverage. Of the 197,975 hospitalizations analyzed, 30% were for pneumonia. Significant declines in hospitalizations for pneumonia were noted in Belo Horizonte (28.7%), Curitiba (23.3%), and Recife (27.4%) but not in São Paulo and Porto Alegre. However, in the latter 2 cities, vaccination coverage was less than that in the former 3. Overall, 1 year after introduction of PCV10, hospitalizations of children for pneumonia were reduced.
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spelling pubmed-36474142013-05-13 Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil Afonso, Eliane Terezinha Minamisava, Ruth Bierrenbach, Ana Luiza Escalante, Juan Jose Cortez Alencar, Airlane Pereira Domingues, Carla Magda Morais-Neto, Otaliba Libanio Toscano, Cristiana Maria Andrade, Ana Lucia Emerg Infect Dis Research Pneumonia is most problematic for children in developing countries. In 2010, Brazil introduced a 10-valent pneumococcal conjugate vaccine (PCV10) to its National Immunization Program. To assess the vaccine’s effectiveness for preventing pneumonia, we analyzed rates of hospitalization among children 2–24 months of age who had pneumonia from all causes from January 2005 through August 2011. We used data from the National Hospitalization Information System to conduct an interrupted time-series analysis for 5 cities in Brazil that had good data quality and high PCV10 vaccination coverage. Of the 197,975 hospitalizations analyzed, 30% were for pneumonia. Significant declines in hospitalizations for pneumonia were noted in Belo Horizonte (28.7%), Curitiba (23.3%), and Recife (27.4%) but not in São Paulo and Porto Alegre. However, in the latter 2 cities, vaccination coverage was less than that in the former 3. Overall, 1 year after introduction of PCV10, hospitalizations of children for pneumonia were reduced. Centers for Disease Control and Prevention 2013-04 /pmc/articles/PMC3647414/ /pubmed/23628462 http://dx.doi.org/10.3201/eid1904.121198 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Afonso, Eliane Terezinha
Minamisava, Ruth
Bierrenbach, Ana Luiza
Escalante, Juan Jose Cortez
Alencar, Airlane Pereira
Domingues, Carla Magda
Morais-Neto, Otaliba Libanio
Toscano, Cristiana Maria
Andrade, Ana Lucia
Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil
title Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil
title_full Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil
title_fullStr Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil
title_full_unstemmed Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil
title_short Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil
title_sort effect of 10-valent pneumococcal vaccine on pneumonia among children, brazil
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647414/
https://www.ncbi.nlm.nih.gov/pubmed/23628462
http://dx.doi.org/10.3201/eid1904.121198
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