Cargando…

Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults

Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007–2008, we enrolled HIV-infected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at...

Descripción completa

Detalles Bibliográficos
Autores principales: Peters, Philip J., Brooks, John T., McAllister, Sigrid K., Limbago, Brandi, Lowery, H. Ken, Fosheim, Gregory, Guest, Jodie L., Gorwitz, Rachel J., Bethea, Monique, Hageman, Jeffrey, Mindley, Rondeen, McDougal, Linda K., Rimland, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647417/
https://www.ncbi.nlm.nih.gov/pubmed/23631854
http://dx.doi.org/10.3201/eid1904.121353
_version_ 1782268731644182528
author Peters, Philip J.
Brooks, John T.
McAllister, Sigrid K.
Limbago, Brandi
Lowery, H. Ken
Fosheim, Gregory
Guest, Jodie L.
Gorwitz, Rachel J.
Bethea, Monique
Hageman, Jeffrey
Mindley, Rondeen
McDougal, Linda K.
Rimland, David
author_facet Peters, Philip J.
Brooks, John T.
McAllister, Sigrid K.
Limbago, Brandi
Lowery, H. Ken
Fosheim, Gregory
Guest, Jodie L.
Gorwitz, Rachel J.
Bethea, Monique
Hageman, Jeffrey
Mindley, Rondeen
McDougal, Linda K.
Rimland, David
author_sort Peters, Philip J.
collection PubMed
description Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007–2008, we enrolled HIV-infected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at enrollment and after 6 and 12 months. MRSA colonization was detected in 13%–15% of HIV-infected participants (n = 600, 98% male) at baseline, 6 months, and 12 months. MRSA colonization was detected in the nares only (41%), groin only (21%), and at both sites (38%). Over a median of 2.1 years of follow-up, 29 MRSA clinical infections occurred in 25 participants. In multivariate analysis, MRSA clinical infection was significantly associated with MRSA colonization of the groin (adjusted risk ratio 4.8) and a history of MRSA infection (adjusted risk ratio 3.1). MRSA prevention strategies that can effectively prevent or eliminate groin colonization are likely necessary to reduce clinical infections in this population.
format Online
Article
Text
id pubmed-3647417
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-36474172013-05-13 Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults Peters, Philip J. Brooks, John T. McAllister, Sigrid K. Limbago, Brandi Lowery, H. Ken Fosheim, Gregory Guest, Jodie L. Gorwitz, Rachel J. Bethea, Monique Hageman, Jeffrey Mindley, Rondeen McDougal, Linda K. Rimland, David Emerg Infect Dis Research Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007–2008, we enrolled HIV-infected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at enrollment and after 6 and 12 months. MRSA colonization was detected in 13%–15% of HIV-infected participants (n = 600, 98% male) at baseline, 6 months, and 12 months. MRSA colonization was detected in the nares only (41%), groin only (21%), and at both sites (38%). Over a median of 2.1 years of follow-up, 29 MRSA clinical infections occurred in 25 participants. In multivariate analysis, MRSA clinical infection was significantly associated with MRSA colonization of the groin (adjusted risk ratio 4.8) and a history of MRSA infection (adjusted risk ratio 3.1). MRSA prevention strategies that can effectively prevent or eliminate groin colonization are likely necessary to reduce clinical infections in this population. Centers for Disease Control and Prevention 2013-04 /pmc/articles/PMC3647417/ /pubmed/23631854 http://dx.doi.org/10.3201/eid1904.121353 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Peters, Philip J.
Brooks, John T.
McAllister, Sigrid K.
Limbago, Brandi
Lowery, H. Ken
Fosheim, Gregory
Guest, Jodie L.
Gorwitz, Rachel J.
Bethea, Monique
Hageman, Jeffrey
Mindley, Rondeen
McDougal, Linda K.
Rimland, David
Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults
title Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults
title_full Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults
title_fullStr Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults
title_full_unstemmed Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults
title_short Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults
title_sort methicillin-resistant staphylococcus aureus colonization of the groin and risk for clinical infection among hiv-infected adults
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647417/
https://www.ncbi.nlm.nih.gov/pubmed/23631854
http://dx.doi.org/10.3201/eid1904.121353
work_keys_str_mv AT petersphilipj methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT brooksjohnt methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT mcallistersigridk methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT limbagobrandi methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT loweryhken methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT fosheimgregory methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT guestjodiel methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT gorwitzrachelj methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT betheamonique methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT hagemanjeffrey methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT mindleyrondeen methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT mcdougallindak methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults
AT rimlanddavid methicillinresistantstaphylococcusaureuscolonizationofthegroinandriskforclinicalinfectionamonghivinfectedadults