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Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults
Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007–2008, we enrolled HIV-infected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647417/ https://www.ncbi.nlm.nih.gov/pubmed/23631854 http://dx.doi.org/10.3201/eid1904.121353 |
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author | Peters, Philip J. Brooks, John T. McAllister, Sigrid K. Limbago, Brandi Lowery, H. Ken Fosheim, Gregory Guest, Jodie L. Gorwitz, Rachel J. Bethea, Monique Hageman, Jeffrey Mindley, Rondeen McDougal, Linda K. Rimland, David |
author_facet | Peters, Philip J. Brooks, John T. McAllister, Sigrid K. Limbago, Brandi Lowery, H. Ken Fosheim, Gregory Guest, Jodie L. Gorwitz, Rachel J. Bethea, Monique Hageman, Jeffrey Mindley, Rondeen McDougal, Linda K. Rimland, David |
author_sort | Peters, Philip J. |
collection | PubMed |
description | Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007–2008, we enrolled HIV-infected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at enrollment and after 6 and 12 months. MRSA colonization was detected in 13%–15% of HIV-infected participants (n = 600, 98% male) at baseline, 6 months, and 12 months. MRSA colonization was detected in the nares only (41%), groin only (21%), and at both sites (38%). Over a median of 2.1 years of follow-up, 29 MRSA clinical infections occurred in 25 participants. In multivariate analysis, MRSA clinical infection was significantly associated with MRSA colonization of the groin (adjusted risk ratio 4.8) and a history of MRSA infection (adjusted risk ratio 3.1). MRSA prevention strategies that can effectively prevent or eliminate groin colonization are likely necessary to reduce clinical infections in this population. |
format | Online Article Text |
id | pubmed-3647417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-36474172013-05-13 Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults Peters, Philip J. Brooks, John T. McAllister, Sigrid K. Limbago, Brandi Lowery, H. Ken Fosheim, Gregory Guest, Jodie L. Gorwitz, Rachel J. Bethea, Monique Hageman, Jeffrey Mindley, Rondeen McDougal, Linda K. Rimland, David Emerg Infect Dis Research Data on the interaction between methicillin-resistant Staphylococcus aureus (MRSA) colonization and clinical infection are limited. During 2007–2008, we enrolled HIV-infected adults in Atlanta, Georgia, USA, in a prospective cohort study. Nares and groin swab specimens were cultured for S. aureus at enrollment and after 6 and 12 months. MRSA colonization was detected in 13%–15% of HIV-infected participants (n = 600, 98% male) at baseline, 6 months, and 12 months. MRSA colonization was detected in the nares only (41%), groin only (21%), and at both sites (38%). Over a median of 2.1 years of follow-up, 29 MRSA clinical infections occurred in 25 participants. In multivariate analysis, MRSA clinical infection was significantly associated with MRSA colonization of the groin (adjusted risk ratio 4.8) and a history of MRSA infection (adjusted risk ratio 3.1). MRSA prevention strategies that can effectively prevent or eliminate groin colonization are likely necessary to reduce clinical infections in this population. Centers for Disease Control and Prevention 2013-04 /pmc/articles/PMC3647417/ /pubmed/23631854 http://dx.doi.org/10.3201/eid1904.121353 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Peters, Philip J. Brooks, John T. McAllister, Sigrid K. Limbago, Brandi Lowery, H. Ken Fosheim, Gregory Guest, Jodie L. Gorwitz, Rachel J. Bethea, Monique Hageman, Jeffrey Mindley, Rondeen McDougal, Linda K. Rimland, David Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults |
title | Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults |
title_full | Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults |
title_fullStr | Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults |
title_full_unstemmed | Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults |
title_short | Methicillin-Resistant Staphylococcus aureus Colonization of the Groin and Risk for Clinical Infection among HIV-infected Adults |
title_sort | methicillin-resistant staphylococcus aureus colonization of the groin and risk for clinical infection among hiv-infected adults |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647417/ https://www.ncbi.nlm.nih.gov/pubmed/23631854 http://dx.doi.org/10.3201/eid1904.121353 |
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