Endoglin: a critical mediator of cardiovascular health

Endoglin (CD105) is a type III auxiliary receptor for the transforming growth factor beta (TGFβ) superfamily. Several lines of evidence suggest that endoglin plays a critical role in maintaining cardiovascular homeostasis. Seemingly disparate disease conditions, including hereditary hemorrhagic tela...

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Detalles Bibliográficos
Autores principales: Kapur, Navin K, Morine, Kevin J, Letarte, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647444/
https://www.ncbi.nlm.nih.gov/pubmed/23662065
http://dx.doi.org/10.2147/VHRM.S29144
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author Kapur, Navin K
Morine, Kevin J
Letarte, Michelle
author_facet Kapur, Navin K
Morine, Kevin J
Letarte, Michelle
author_sort Kapur, Navin K
collection PubMed
description Endoglin (CD105) is a type III auxiliary receptor for the transforming growth factor beta (TGFβ) superfamily. Several lines of evidence suggest that endoglin plays a critical role in maintaining cardiovascular homeostasis. Seemingly disparate disease conditions, including hereditary hemorrhagic telangiectasia, pre-eclampsia, and cardiac fibrosis, have now been associated with endoglin. Given the central role of the TGFβ superfamily in multiple disease conditions, this review provides a detailed update on endoglin as an evolving therapeutic target in the management of cardiovascular disease.
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spelling pubmed-36474442013-05-09 Endoglin: a critical mediator of cardiovascular health Kapur, Navin K Morine, Kevin J Letarte, Michelle Vasc Health Risk Manag Review Endoglin (CD105) is a type III auxiliary receptor for the transforming growth factor beta (TGFβ) superfamily. Several lines of evidence suggest that endoglin plays a critical role in maintaining cardiovascular homeostasis. Seemingly disparate disease conditions, including hereditary hemorrhagic telangiectasia, pre-eclampsia, and cardiac fibrosis, have now been associated with endoglin. Given the central role of the TGFβ superfamily in multiple disease conditions, this review provides a detailed update on endoglin as an evolving therapeutic target in the management of cardiovascular disease. Dove Medical Press 2013 2013-05-06 /pmc/articles/PMC3647444/ /pubmed/23662065 http://dx.doi.org/10.2147/VHRM.S29144 Text en © 2013 Kapur et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Kapur, Navin K
Morine, Kevin J
Letarte, Michelle
Endoglin: a critical mediator of cardiovascular health
title Endoglin: a critical mediator of cardiovascular health
title_full Endoglin: a critical mediator of cardiovascular health
title_fullStr Endoglin: a critical mediator of cardiovascular health
title_full_unstemmed Endoglin: a critical mediator of cardiovascular health
title_short Endoglin: a critical mediator of cardiovascular health
title_sort endoglin: a critical mediator of cardiovascular health
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647444/
https://www.ncbi.nlm.nih.gov/pubmed/23662065
http://dx.doi.org/10.2147/VHRM.S29144
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