Effect of V(IV)O(dipic-Cl)(H(2)O)(2) on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats

Vanadium complexes are potent antidiabetic agents for therapeutical treatment of diabetes. In the present study, we investigated the hypolipidemic effect of V(IV)O(dipic-Cl)(H(2)O)(2) (V(4)dipic-Cl) in liver of streptozotocin- (STZ-)-induced diabetic rats. We found that diabetic animals exhibited he...

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Detalles Bibliográficos
Autores principales: Liu, Fang, Xie, Mingxia, Chen, Deliang, Li, Jian, Ding, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647472/
https://www.ncbi.nlm.nih.gov/pubmed/23691525
http://dx.doi.org/10.1155/2013/956737
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author Liu, Fang
Xie, Mingxia
Chen, Deliang
Li, Jian
Ding, Wenjun
author_facet Liu, Fang
Xie, Mingxia
Chen, Deliang
Li, Jian
Ding, Wenjun
author_sort Liu, Fang
collection PubMed
description Vanadium complexes are potent antidiabetic agents for therapeutical treatment of diabetes. In the present study, we investigated the hypolipidemic effect of V(IV)O(dipic-Cl)(H(2)O)(2) (V(4)dipic-Cl) in liver of streptozotocin- (STZ-)-induced diabetic rats. We found that diabetic animals exhibited hepatic inflammatory infiltration and impaired liver function along with triglyceride (TG) accumulation in the liver. V(4)dipic-Cl treatment not only ameliorated liver pathological state but also reduced hepatic TG level. Moreover, the upregulation of fatty acid translocase (FAT/CD36) mRNA (4.0-fold) and protein (8.2-fold) levels in the liver of diabetic rats were significantly reversed after V(4)dipic-Cl treatment. However, no significant effects of V(4)dipic-Cl on the mRNA expression of fatty acid metabolism-related fatty acid bounding protein 1 (FABP1) and fatty acid transporter 5 (FATP5) were observed. These results suggest that the modification of lipid metabolism-related FAT/CD36 in the liver of diabetic rats is likely involved in the hypolipidemic effects of V(4)dipic-Cl.
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spelling pubmed-36474722013-05-20 Effect of V(IV)O(dipic-Cl)(H(2)O)(2) on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats Liu, Fang Xie, Mingxia Chen, Deliang Li, Jian Ding, Wenjun J Diabetes Res Research Article Vanadium complexes are potent antidiabetic agents for therapeutical treatment of diabetes. In the present study, we investigated the hypolipidemic effect of V(IV)O(dipic-Cl)(H(2)O)(2) (V(4)dipic-Cl) in liver of streptozotocin- (STZ-)-induced diabetic rats. We found that diabetic animals exhibited hepatic inflammatory infiltration and impaired liver function along with triglyceride (TG) accumulation in the liver. V(4)dipic-Cl treatment not only ameliorated liver pathological state but also reduced hepatic TG level. Moreover, the upregulation of fatty acid translocase (FAT/CD36) mRNA (4.0-fold) and protein (8.2-fold) levels in the liver of diabetic rats were significantly reversed after V(4)dipic-Cl treatment. However, no significant effects of V(4)dipic-Cl on the mRNA expression of fatty acid metabolism-related fatty acid bounding protein 1 (FABP1) and fatty acid transporter 5 (FATP5) were observed. These results suggest that the modification of lipid metabolism-related FAT/CD36 in the liver of diabetic rats is likely involved in the hypolipidemic effects of V(4)dipic-Cl. Hindawi Publishing Corporation 2013 2013-03-20 /pmc/articles/PMC3647472/ /pubmed/23691525 http://dx.doi.org/10.1155/2013/956737 Text en Copyright © 2013 Fang Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Fang
Xie, Mingxia
Chen, Deliang
Li, Jian
Ding, Wenjun
Effect of V(IV)O(dipic-Cl)(H(2)O)(2) on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats
title Effect of V(IV)O(dipic-Cl)(H(2)O)(2) on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats
title_full Effect of V(IV)O(dipic-Cl)(H(2)O)(2) on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats
title_fullStr Effect of V(IV)O(dipic-Cl)(H(2)O)(2) on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats
title_full_unstemmed Effect of V(IV)O(dipic-Cl)(H(2)O)(2) on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats
title_short Effect of V(IV)O(dipic-Cl)(H(2)O)(2) on Lipid Metabolism Disorders in the Liver of STZ-Induced Diabetic Rats
title_sort effect of v(iv)o(dipic-cl)(h(2)o)(2) on lipid metabolism disorders in the liver of stz-induced diabetic rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647472/
https://www.ncbi.nlm.nih.gov/pubmed/23691525
http://dx.doi.org/10.1155/2013/956737
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