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Spontaneous Type 2 Diabetic Rodent Models
Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647580/ https://www.ncbi.nlm.nih.gov/pubmed/23671868 http://dx.doi.org/10.1155/2013/401723 |
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author | Wang, Yang-wei Sun, Guang-dong Sun, Jing Liu, Shu-jun Wang, Ji Xu, Xiao-hong Miao, Li-ning |
author_facet | Wang, Yang-wei Sun, Guang-dong Sun, Jing Liu, Shu-jun Wang, Ji Xu, Xiao-hong Miao, Li-ning |
author_sort | Wang, Yang-wei |
collection | PubMed |
description | Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress of T2DM and find effective treatments for its complications. On the basis of their strains, features, advantages, and disadvantages, various types of animal models of T2DM can be divided into spontaneously diabetic models, artificially induced diabetic models, and transgenic/knockout diabetic models. Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. In this paper, we aim to investigate the current available spontaneous rodent models for T2DM with regard to their characteristic features, advantages, and disadvantages, and especially to describe appropriate selection and usefulness of different spontaneous rodent models in testing of various new antidiabetic drugs for the treatment of type 2 diabetes. |
format | Online Article Text |
id | pubmed-3647580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36475802013-05-13 Spontaneous Type 2 Diabetic Rodent Models Wang, Yang-wei Sun, Guang-dong Sun, Jing Liu, Shu-jun Wang, Ji Xu, Xiao-hong Miao, Li-ning J Diabetes Res Review Article Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress of T2DM and find effective treatments for its complications. On the basis of their strains, features, advantages, and disadvantages, various types of animal models of T2DM can be divided into spontaneously diabetic models, artificially induced diabetic models, and transgenic/knockout diabetic models. Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. In this paper, we aim to investigate the current available spontaneous rodent models for T2DM with regard to their characteristic features, advantages, and disadvantages, and especially to describe appropriate selection and usefulness of different spontaneous rodent models in testing of various new antidiabetic drugs for the treatment of type 2 diabetes. Hindawi Publishing Corporation 2013 2013-02-28 /pmc/articles/PMC3647580/ /pubmed/23671868 http://dx.doi.org/10.1155/2013/401723 Text en Copyright © 2013 Yang-wei Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Yang-wei Sun, Guang-dong Sun, Jing Liu, Shu-jun Wang, Ji Xu, Xiao-hong Miao, Li-ning Spontaneous Type 2 Diabetic Rodent Models |
title | Spontaneous Type 2 Diabetic Rodent Models |
title_full | Spontaneous Type 2 Diabetic Rodent Models |
title_fullStr | Spontaneous Type 2 Diabetic Rodent Models |
title_full_unstemmed | Spontaneous Type 2 Diabetic Rodent Models |
title_short | Spontaneous Type 2 Diabetic Rodent Models |
title_sort | spontaneous type 2 diabetic rodent models |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647580/ https://www.ncbi.nlm.nih.gov/pubmed/23671868 http://dx.doi.org/10.1155/2013/401723 |
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