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Spontaneous Type 2 Diabetic Rodent Models

Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress...

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Autores principales: Wang, Yang-wei, Sun, Guang-dong, Sun, Jing, Liu, Shu-jun, Wang, Ji, Xu, Xiao-hong, Miao, Li-ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647580/
https://www.ncbi.nlm.nih.gov/pubmed/23671868
http://dx.doi.org/10.1155/2013/401723
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author Wang, Yang-wei
Sun, Guang-dong
Sun, Jing
Liu, Shu-jun
Wang, Ji
Xu, Xiao-hong
Miao, Li-ning
author_facet Wang, Yang-wei
Sun, Guang-dong
Sun, Jing
Liu, Shu-jun
Wang, Ji
Xu, Xiao-hong
Miao, Li-ning
author_sort Wang, Yang-wei
collection PubMed
description Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress of T2DM and find effective treatments for its complications. On the basis of their strains, features, advantages, and disadvantages, various types of animal models of T2DM can be divided into spontaneously diabetic models, artificially induced diabetic models, and transgenic/knockout diabetic models. Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. In this paper, we aim to investigate the current available spontaneous rodent models for T2DM with regard to their characteristic features, advantages, and disadvantages, and especially to describe appropriate selection and usefulness of different spontaneous rodent models in testing of various new antidiabetic drugs for the treatment of type 2 diabetes.
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spelling pubmed-36475802013-05-13 Spontaneous Type 2 Diabetic Rodent Models Wang, Yang-wei Sun, Guang-dong Sun, Jing Liu, Shu-jun Wang, Ji Xu, Xiao-hong Miao, Li-ning J Diabetes Res Review Article Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress of T2DM and find effective treatments for its complications. On the basis of their strains, features, advantages, and disadvantages, various types of animal models of T2DM can be divided into spontaneously diabetic models, artificially induced diabetic models, and transgenic/knockout diabetic models. Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. In this paper, we aim to investigate the current available spontaneous rodent models for T2DM with regard to their characteristic features, advantages, and disadvantages, and especially to describe appropriate selection and usefulness of different spontaneous rodent models in testing of various new antidiabetic drugs for the treatment of type 2 diabetes. Hindawi Publishing Corporation 2013 2013-02-28 /pmc/articles/PMC3647580/ /pubmed/23671868 http://dx.doi.org/10.1155/2013/401723 Text en Copyright © 2013 Yang-wei Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Yang-wei
Sun, Guang-dong
Sun, Jing
Liu, Shu-jun
Wang, Ji
Xu, Xiao-hong
Miao, Li-ning
Spontaneous Type 2 Diabetic Rodent Models
title Spontaneous Type 2 Diabetic Rodent Models
title_full Spontaneous Type 2 Diabetic Rodent Models
title_fullStr Spontaneous Type 2 Diabetic Rodent Models
title_full_unstemmed Spontaneous Type 2 Diabetic Rodent Models
title_short Spontaneous Type 2 Diabetic Rodent Models
title_sort spontaneous type 2 diabetic rodent models
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647580/
https://www.ncbi.nlm.nih.gov/pubmed/23671868
http://dx.doi.org/10.1155/2013/401723
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