Cargando…

A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat

The Zucker fatty (ZF) rat harboring a missense mutation (fatty, fa) in the leptin receptor gene (Lepr) develops obesity without diabetes; Zucker diabetic fatty (ZDF) rats derived from the ZF strain exhibit obesity with diabetes and are widely used for research on type 2 diabetes (T2D). Here we estab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yokoi, Norihide, Hoshino, Masayuki, Hidaka, Shihomi, Yoshida, Eri, Beppu, Masayuki, Hoshikawa, Ritsuko, Sudo, Katsuko, Kawada, Akihiko, Takagi, Sadaaki, Seino, Susumu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647587/ https://www.ncbi.nlm.nih.gov/pubmed/23671847 http://dx.doi.org/10.1155/2013/103731

Ejemplares similares

Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat
por: Gheni, Ghupurjan, et al.
Publicado: (2015)

Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes
por: Yokoi, Norihide, et al.
Publicado: (2015)

Tumor‐like features of gene expression and metabolic profiles in enlarged pancreatic islets are associated with impaired incretin‐induced insulin secretion in obese diabetes: A study of Zucker fatty diabetes mellitus rat
por: Hayami, Tomohide, et al.
Publicado: (2020)

Genetic profiling of two phenotypically distinct outbred rats derived from a colony of the Zucker fatty rats maintained at Tokyo Medical University
por: Nakanishi, Satoshi, et al.
Publicado: (2016)

Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats
por: Yokoi, N, et al.
Publicado: (2012)

Coenzyme A and Its Thioester Pools in Obese Zucker and Zucker Diabetic Fatty Rats
por: Chohnan, Shigeru, et al.
Publicado: (2020)

Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
por: van den Brom, Charissa E, et al.
Publicado: (2010)

Cognitive Performance during the Development of Diabetes in the Zucker Diabetic Fatty Rat
por: Spoelder, Marcia, et al.
Publicado: (2023)

Elevated pulmonary arterial pressure in Zucker diabetic fatty rats
por: Morales-Cano, Daniel, et al.
Publicado: (2019)

Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model – the Zucker diabetic rat
por: Forcheron, Fabien, et al.
Publicado: (2009)

Histological Evaluation of Diabetic Neurodegeneration in the Retina of Zucker Diabetic Fatty (ZDF) Rats
por: Szabó, Klaudia, et al.
Publicado: (2017)

Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats
por: Kim, Junghyun, et al.
Publicado: (2013)

Preventive effects of Morus alba L. anthocyanins on diabetes in Zucker diabetic fatty rats
por: SARIKAPHUTI, ARIYA, et al.
Publicado: (2013)

Anti-Obesity Effects of Onion Extract in Zucker Diabetic Fatty Rats
por: Yoshinari, Orie, et al.
Publicado: (2012)

The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications
por: Sasase, Tomohiko, et al.
Publicado: (2013)

Dynamic Development of Fecal Microbiome During the Progression of Diabetes Mellitus in Zucker Diabetic Fatty Rats
por: Zhou, Wen, et al.
Publicado: (2019)

Zucker Diabetic‐Sprague Dawley (ZDSD) rat: Type 2 diabetes translational research model
por: Wang, Andrea N., et al.
Publicado: (2022)

Expression of fourteen novel obesity-related genes in zucker diabetic fatty rats
por: Schmid, Peter M, et al.
Publicado: (2012)

Caloric restriction or telmisartan control dyslipidemia and nephropathy in obese diabetic Zücker rats
por: Lezcano, Eduardo J, et al.
Publicado: (2014)

Melatonin Improves Mitochondrial Dynamics and Function in the Kidney of Zücker Diabetic Fatty Rats
por: Agil, Ahmad, et al.
Publicado: (2020)

The Prostacyclin Analog Beraprost Sodium Ameliorates Characteristics of Metabolic Syndrome in Obese Zucker (Fatty) Rats
por: Sato, Nahoko, et al.
Publicado: (2010)

Xenogeneic transplantation of human adipose-derived stem cell sheets accelerate angiogenesis and the healing of skin wounds in a Zucker Diabetic Fatty rat model of obese diabetes
por: Hamada, Mariko, et al.
Publicado: (2017)

Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat
por: VanHoose, Lisa, et al.
Publicado: (2010)

Cardiac and renal function are progressively impaired with aging in Zucker diabetic fatty type II diabetic rats
por: Baynes, John, et al.
Publicado: (2009)

Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses
por: Haley, James M., et al.
Publicado: (2015)

Influence of diabetes mellitus duration on the efficacy of ischemic preconditioning in a Zucker diabetic fatty rat model
por: Hjortbak, Marie Vognstoft, et al.
Publicado: (2018)

Characterization of Micro-RNA Changes during the Progression of Type 2 Diabetes in Zucker Diabetic Fatty Rats
por: Delic, Denis, et al.
Publicado: (2016)

Reduction in the Dietary VA Status Prevents Type 2 Diabetes and Obesity in Zucker Diabetic Fatty Rats
por: Wang, Tiannan, et al.
Publicado: (2022)

Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes
por: Otani, Kosuke, et al.
Publicado: (2022)

Multimodal Comparison of Diabetic Neuropathy in Aged Streptozotocin-Treated Sprague–Dawley and Zucker Diabetic Fatty Rats
por: Canta, Annalisa, et al.
Publicado: (2022)

The Metal Chelators, Trientine and Citrate, Inhibit the Development of Cardiac Pathology in the Zucker Diabetic Rat
por: Baynes, John W., et al.
Publicado: (2009)

Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
por: Lu, Xiao, et al.
Publicado: (2010)

Raloxifene Prevents Skeletal Fragility in Adult Female Zucker Diabetic Sprague-Dawley Rats
por: Hill Gallant, Kathleen M., et al.
Publicado: (2014)

Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals
por: Wang, Xi, et al.
Publicado: (2014)

NADPH Oxidase 2-Mediated Insult in the Auditory Cortex of Zucker Diabetic Fatty Rats
por: Du, Zheng-De, et al.
Publicado: (2019)

Effects of metformin, acarbose, and sitagliptin monotherapy on gut microbiota in Zucker diabetic fatty rats
por: Zhang, Minchun, et al.
Publicado: (2019)

Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats
por: Sui, Yi, et al.
Publicado: (2019)

Effect of Tangshen formula on the remodeling of small intestine and colon in Zucker diabetic fatty rats
por: Yang, Xin, et al.
Publicado: (2023)

Characterization of Diabetic Neuropathy in the Zucker Diabetic Sprague-Dawley Rat: A New Animal Model for Type 2 Diabetes
por: Davidson, Eric P., et al.
Publicado: (2014)

Ocular findings in Zucker Diabetic Fatty rats emphasize the key role of neuroglia degeneration in diabetic retinopathy pathophysiology
por: Fernandez-Bueno, Ivan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1dbflhik4pf9sj7a862ic899bk