Contribution of the R8 substituent to the in vitro antibacterial potency of besifloxacin and comparator ophthalmic fluoroquinolones

INTRODUCTION: Previous work has shown that besifloxacin, an 8-chloro-fluoroquinolone, has more potent activity against gram-positive pathogens than moxifloxacin and gatifloxacin, which carry an 8-methoxy group. This study was conducted to determine the contribution of the R7 and R8 substituent to fl...

Descripción completa

Detalles Bibliográficos
Autores principales: Haas, Wolfgang, Sanfilippo, Christine M, Hesje, Christine K, Morris, Timothy W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647603/
https://www.ncbi.nlm.nih.gov/pubmed/23662042
http://dx.doi.org/10.2147/OPTH.S44085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647603/
https://www.ncbi.nlm.nih.gov/pubmed/23662042
http://dx.doi.org/10.2147/OPTH.S44085

Ejemplares similares