2-Methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate

In the title solvate, C(17)H(20)N(4)S·2C(3)H(8)O, pairs of olanzapine mol­ecules related by a centre of inversion stack along the a axis, forming columns, which are packed parallel to each other along the b axis, forming a sheet arrangement. The columns within these sheets are hydrogen bonded to eac...

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Detalles Bibliográficos
Autores principales: Bhardwaj, Rajni M., Florence, Alastair J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648280/
https://www.ncbi.nlm.nih.gov/pubmed/23723900
http://dx.doi.org/10.1107/S1600536813009811
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author Bhardwaj, Rajni M.
Florence, Alastair J.
author_facet Bhardwaj, Rajni M.
Florence, Alastair J.
author_sort Bhardwaj, Rajni M.
collection PubMed
description In the title solvate, C(17)H(20)N(4)S·2C(3)H(8)O, pairs of olanzapine mol­ecules related by a centre of inversion stack along the a axis, forming columns, which are packed parallel to each other along the b axis, forming a sheet arrangement. The columns within these sheets are hydrogen bonded to each other through the propan-2-ol solvent mol­ecules. The diazepine ring of the olanzapine exists in a puckered conformation with the thiophene and phenyl rings making a dihedral angle of 57.66 (7)° and the piperazine ring adopts a chair conformation with the methyl group in an equatorial position.
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spelling pubmed-36482802013-05-30 2-Methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate Bhardwaj, Rajni M. Florence, Alastair J. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title solvate, C(17)H(20)N(4)S·2C(3)H(8)O, pairs of olanzapine mol­ecules related by a centre of inversion stack along the a axis, forming columns, which are packed parallel to each other along the b axis, forming a sheet arrangement. The columns within these sheets are hydrogen bonded to each other through the propan-2-ol solvent mol­ecules. The diazepine ring of the olanzapine exists in a puckered conformation with the thiophene and phenyl rings making a dihedral angle of 57.66 (7)° and the piperazine ring adopts a chair conformation with the methyl group in an equatorial position. International Union of Crystallography 2013-04-20 /pmc/articles/PMC3648280/ /pubmed/23723900 http://dx.doi.org/10.1107/S1600536813009811 Text en © Bhardwaj and Florence 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Bhardwaj, Rajni M.
Florence, Alastair J.
2-Methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate
title 2-Methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate
title_full 2-Methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate
title_fullStr 2-Methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate
title_full_unstemmed 2-Methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate
title_short 2-Methyl-4-(4-methyl­piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate
title_sort 2-methyl-4-(4-methyl­piperazin-1-yl)-10h-thieno[2,3-b][1,5]benzodiazepine (olanzapine) propan-2-ol disolvate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648280/
https://www.ncbi.nlm.nih.gov/pubmed/23723900
http://dx.doi.org/10.1107/S1600536813009811
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