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Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona

BACKGROUND: Serum 25-hydroxyvitamin D3 (Vitamin D) insufficiency and single-nucleotide polymorphisms (SNPs) on its receptor, Vitamin D receptor (VDR), have been reported to be involved in melanoma susceptibility in populations mostly from northern countries. OBJECTIVE: To investigate 25-hydroxyvitam...

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Autores principales: Ogbah, Zighereda, Visa, Laura, Badenas, Celia, Ríos, José, Puig-Butille, Joan Anton, Bonifaci, Nuria, Guino, Elisabet, Augé, Josep Maria, Kolm, Isabel, Carrera, Cristina, Pujana, Miquel Ángel, Malvehy, Josep, Puig, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648347/
https://www.ncbi.nlm.nih.gov/pubmed/23413917
http://dx.doi.org/10.1186/1471-2350-14-26
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author Ogbah, Zighereda
Visa, Laura
Badenas, Celia
Ríos, José
Puig-Butille, Joan Anton
Bonifaci, Nuria
Guino, Elisabet
Augé, Josep Maria
Kolm, Isabel
Carrera, Cristina
Pujana, Miquel Ángel
Malvehy, Josep
Puig, Susana
author_facet Ogbah, Zighereda
Visa, Laura
Badenas, Celia
Ríos, José
Puig-Butille, Joan Anton
Bonifaci, Nuria
Guino, Elisabet
Augé, Josep Maria
Kolm, Isabel
Carrera, Cristina
Pujana, Miquel Ángel
Malvehy, Josep
Puig, Susana
author_sort Ogbah, Zighereda
collection PubMed
description BACKGROUND: Serum 25-hydroxyvitamin D3 (Vitamin D) insufficiency and single-nucleotide polymorphisms (SNPs) on its receptor, Vitamin D receptor (VDR), have been reported to be involved in melanoma susceptibility in populations mostly from northern countries. OBJECTIVE: To investigate 25-hydroxyvitamin D3 levels and VDR SNPs in melanoma patients from sunny area of Barcelona, two studies were carried out. The first study evaluated the levels of Vitamin D at time of melanoma diagnosis and the second one analyzed the association between VDR genetic variants and risk of having a high nevus number, the strongest phenotypic risk factor for melanoma. METHODS: The levels of 25-hydroxyvitamin D3 in 81 melanoma patients at diagnosis were measured. In a second group of melanoma patients, including 150 with low and 113 with high nevus number, 11 VDR SNPs were analyzed for their association with nevus number. RESULTS: In the first study, 68% of patients had insufficient levels of 25-hydroxyvitamin D3 (<25 ng/ml). Autumn-winter months and fair phototype were associated with 25-hydroxyvitamin D3 insufficiency; after multivariate analysis, season of sampling remained the only independent predictor of 25-hydroxyvitamin D3 levels. In the second study, VDR variant rs2189480 (P = 0.006) was associated with risk of high nevus number whereas rs2239179 (P = 0.044) and rs7975128 (P = 0.0005) were protective against high nevus number. After Bonferroni adjustment only rs7975128 remained significant. In stratified analysis, SNP rs7975128 was found protective against multiple melanomas (P = 0.021). CONCLUSION: This study showed that even in Barcelona, a sunny Mediterranean area, 25-hydroxyvitamin D3 levels were sub-optimal in the majority of melanoma patients at diagnosis. The involvement of VDR in nevi and, in turn, in melanoma susceptibility has also been suggested. Larger studies are needed to confirm our findings.
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spelling pubmed-36483472013-05-09 Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona Ogbah, Zighereda Visa, Laura Badenas, Celia Ríos, José Puig-Butille, Joan Anton Bonifaci, Nuria Guino, Elisabet Augé, Josep Maria Kolm, Isabel Carrera, Cristina Pujana, Miquel Ángel Malvehy, Josep Puig, Susana BMC Med Genet Research Article BACKGROUND: Serum 25-hydroxyvitamin D3 (Vitamin D) insufficiency and single-nucleotide polymorphisms (SNPs) on its receptor, Vitamin D receptor (VDR), have been reported to be involved in melanoma susceptibility in populations mostly from northern countries. OBJECTIVE: To investigate 25-hydroxyvitamin D3 levels and VDR SNPs in melanoma patients from sunny area of Barcelona, two studies were carried out. The first study evaluated the levels of Vitamin D at time of melanoma diagnosis and the second one analyzed the association between VDR genetic variants and risk of having a high nevus number, the strongest phenotypic risk factor for melanoma. METHODS: The levels of 25-hydroxyvitamin D3 in 81 melanoma patients at diagnosis were measured. In a second group of melanoma patients, including 150 with low and 113 with high nevus number, 11 VDR SNPs were analyzed for their association with nevus number. RESULTS: In the first study, 68% of patients had insufficient levels of 25-hydroxyvitamin D3 (<25 ng/ml). Autumn-winter months and fair phototype were associated with 25-hydroxyvitamin D3 insufficiency; after multivariate analysis, season of sampling remained the only independent predictor of 25-hydroxyvitamin D3 levels. In the second study, VDR variant rs2189480 (P = 0.006) was associated with risk of high nevus number whereas rs2239179 (P = 0.044) and rs7975128 (P = 0.0005) were protective against high nevus number. After Bonferroni adjustment only rs7975128 remained significant. In stratified analysis, SNP rs7975128 was found protective against multiple melanomas (P = 0.021). CONCLUSION: This study showed that even in Barcelona, a sunny Mediterranean area, 25-hydroxyvitamin D3 levels were sub-optimal in the majority of melanoma patients at diagnosis. The involvement of VDR in nevi and, in turn, in melanoma susceptibility has also been suggested. Larger studies are needed to confirm our findings. BioMed Central 2013-02-16 /pmc/articles/PMC3648347/ /pubmed/23413917 http://dx.doi.org/10.1186/1471-2350-14-26 Text en Copyright © 2013 Ogbah et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ogbah, Zighereda
Visa, Laura
Badenas, Celia
Ríos, José
Puig-Butille, Joan Anton
Bonifaci, Nuria
Guino, Elisabet
Augé, Josep Maria
Kolm, Isabel
Carrera, Cristina
Pujana, Miquel Ángel
Malvehy, Josep
Puig, Susana
Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona
title Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona
title_full Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona
title_fullStr Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona
title_full_unstemmed Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona
title_short Serum 25-hydroxyvitamin D3 levels and vitamin D receptor variants in melanoma patients from the Mediterranean area of Barcelona
title_sort serum 25-hydroxyvitamin d3 levels and vitamin d receptor variants in melanoma patients from the mediterranean area of barcelona
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648347/
https://www.ncbi.nlm.nih.gov/pubmed/23413917
http://dx.doi.org/10.1186/1471-2350-14-26
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