Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial

BACKGROUND: Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. Kv7 channels are expressed along myelinated and unmyelinated peripheral axons where their activation is expected to reduce axonal excitability and potentially contribute to flupirtine’s clin...

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Detalles Bibliográficos
Autores principales: Fleckenstein, Johannes, Sittl, Ruth, Averbeck, Beate, Lang, Philip M, Irnich, Dominik, Carr, Richard W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648471/
https://www.ncbi.nlm.nih.gov/pubmed/23394517
http://dx.doi.org/10.1186/1479-5876-11-34

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