A Phenylalanine to Serine Substitution within an O-Protein Mannosyltransferase Led to Strong Resistance to PMT-Inhibitors in Pichia pastoris

Protein O-mannosyltransferases (PMTs) catalyze the initial reaction of protein O-mannosylation by transferring the first mannose unit onto serine and threonine residues of a nascent polypeptide being synthesized in the endoplasmic reticulum (ER). The PMTs are well conserved in eukaryotic organisms,...

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Detalles Bibliográficos
Autores principales: Argyros, Rebecca, Nelson, Stephanie, Kull, Angela, Chen, Ming-Tang, Stadheim, Terrance A., Jiang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648545/
https://www.ncbi.nlm.nih.gov/pubmed/23667461
http://dx.doi.org/10.1371/journal.pone.0062229

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