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Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia
Considerable evidence implicates hypoxia and vascular inflammation in Alzheimer's disease (AD). Thrombin, a multifunctional inflammatory mediator, is demonstrable in the brains of AD patients both in the vessel walls and senile plaques. Hypoxia-inducible factor 1α (HIF-1α), a key regulator of t...
Autores principales: | Tripathy, Debjani, Sanchez, Alma, Yin, Xiangling, Luo, Jinhua, Martinez, Joseph, Grammas, Paula |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648692/ https://www.ncbi.nlm.nih.gov/pubmed/23675346 http://dx.doi.org/10.3389/fnagi.2013.00019 |
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