Cargando…

Clostridium difficile Binary Toxin CDT Induces Clustering of the Lipolysis-Stimulated Lipoprotein Receptor into Lipid Rafts

Clostridium difficile is the leading cause of antibiotics-associated diarrhea and pseudomembranous colitis. Hypervirulent C. difficile strains produce the binary actin-ADP-ribosylating toxin CDT (C. difficile transferase), in addition to the Rho-glucosylating toxins A and B. We recently identified t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Papatheodorou, Panagiotis, Hornuss, Daniel, Nölke, Thilo, Hemmasi, Sarah, Castonguay, Jan, Picchianti, Monica, Aktories, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648903/ https://www.ncbi.nlm.nih.gov/pubmed/23631918 http://dx.doi.org/10.1128/mBio.00244-13

Ejemplares similares

Clostridium difficile binary toxin CDT: Mechanism, epidemiology, and potential clinical importance
por: Gerding, Dale N, et al.
Publicado: (2014)

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia
por: Cowardin, Carrie A., et al.
Publicado: (2016)

Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT
por: Unger, Mandy, et al.
Publicado: (2015)

Tailored Cyclodextrin Pore Blocker Protects Mammalian Cells from Clostridium difficile Binary Toxin CDT
por: Roeder, Maurice, et al.
Publicado: (2014)

Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT
por: Korbmacher, Michael, et al.
Publicado: (2020)

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin
por: Schnell, Leonie, et al.
Publicado: (2016)

The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains
por: Beer, Lara-Antonia, et al.
Publicado: (2018)

Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria
por: Schwan, Carsten, et al.
Publicado: (2009)

Prevalence of binary-toxin genes (cdtA and cdtB) among clinical strains of Clostridium difficile isolated from diarrheal patients in Iran
por: Azimirad, Masoumeh, et al.
Publicado: (2018)

Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
por: Kuehne, Sarah A., et al.
Publicado: (2014)

Phosphorylation and functionality of CdtR in Clostridium difficile
por: Bilverstone, T.W., et al.
Publicado: (2019)

A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways
por: Schwartz, Ruth, et al.
Publicado: (2020)

Binary Toxin and Death after Clostridium difficile Infection
por: Bacci, Sabrina, et al.
Publicado: (2011)

Interaction of Clostridium perfringens Iota Toxin and Lipolysis-Stimulated Lipoprotein Receptor (LSR)
por: Nagahama, Masahiro, et al.
Publicado: (2018)

Clostridium difficile Infection Caused by Binary Toxin–Positive Strains
por: Hensgens, Marjolein P.M., et al.
Publicado: (2013)

Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL
por: Schorch, Björn, et al.
Publicado: (2018)

CdtR Regulates TcdA and TcdB Production in Clostridium difficile
por: Lyon, Shelley A., et al.
Publicado: (2016)

Prevalence and pathogenicity of binary toxin–positive Clostridium difficile strains that do not produce toxins A and B
por: Eckert, C., et al.
Publicado: (2014)

Study of the frequency of Clostridium difficile tcdA, tcdB, cdtA and cdtB genes in feces of Calves in south west of Iran
por: Doosti, Abbas, et al.
Publicado: (2014)

Isolation of Clostridium difficile and molecular detection of binary and A/B toxins in faeces of dogs
por: Ghavidel, M., et al.
Publicado: (2016)

Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin
por: Davies, Abigail H., et al.
Publicado: (2016)

Virulence of new variant strains of Clostridium difficile producing only toxin A or binary toxin in the hamster model
por: Marvaud, J.-C., et al.
Publicado: (2019)

The Enterotoxicity of Clostridium difficile Toxins
por: Sun, Xingmin, et al.
Publicado: (2010)

Clinical and Microbiologic Characteristics of Clostridium difficile Infection Caused by Binary Toxin Producing Strain in Korea
por: Kim, Jieun, et al.
Publicado: (2013)

Prevalence of binary toxin positive Clostridium difficile in diarrhoeal humans in the absence of epidemic ribotype 027
por: McGovern, Alan M., et al.
Publicado: (2017)

Rapid visual detection of binary toxin producing Clostridium difficile by loop-mediated isothermal amplification
por: Yu, Lan, et al.
Publicado: (2017)

An Update on Clostridioides difficile Binary Toxin
por: Martínez-Meléndez, Adrián, et al.
Publicado: (2022)

Development of Clostridium difficile R20291ΔPaLoc model strains and in vitro methodologies reveals CdtR is required for the production of CDT to cytotoxic levels
por: Bilverstone, T.W., et al.
Publicado: (2017)

Another surprise in receptor binding of C. difficile toxins
por: Aktories, Klaus
Publicado: (2022)

Challenging the roles of CD44 and lipolysis stimulated lipoprotein receptor in conveying Clostridium perfringens iota toxin cytotoxicity in breast cancer
por: Fagan-Solis, Katerina D, et al.
Publicado: (2014)

Impact of CDT Toxin on Human Diseases
por: Faïs, Tiphanie, et al.
Publicado: (2016)

The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Clostridium difficile Toxin TcdB
por: Zhu, Ziyu, et al.
Publicado: (2019)

Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells
por: Marquardt, Isabel, et al.
Publicado: (2021)

Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins
por: Dixon, Shandee D., et al.
Publicado: (2015)

Growth Patterns of Clostridium difficile – Correlations with Strains, Binary Toxin and Disease Severity: A Prospective Cohort Study
por: Tschudin-Sutter, Sarah, et al.
Publicado: (2016)

Whole genome sequences of three Clade 3 Clostridium difficile strains carrying binary toxin genes in China
por: Chen, Rong, et al.
Publicado: (2017)

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a di-heptamer macromolecular assembly
por: Xu, Xingjian, et al.
Publicado: (2020)

Clostridial Glucosylating Toxins Enter Cells via Clathrin-Mediated Endocytosis
por: Papatheodorou, Panagiotis, et al.
Publicado: (2010)

Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
por: Tao, Liang, et al.
Publicado: (2019)

Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
por: Genth, Harald, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ctbu8tfq6s5gap5r2rveuvrq77