Cargando…

In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction

The involvement of toll-like receptor 9 (TLR9), a receptor for bacterial DNA, in septic cardiac depression has not been clarified in vivo. Thus, the aim of the study was to test possible TLR9 inhibitors (H154-thioate, IRS954-thioate, and chloroquine) for their ability to protect the cardiovascular s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boehm, O., Markowski, P., van der Giet, M., Gielen, V., Kokalova, A., Brill, C., Hoeft, A., Baumgarten, G., Meyer, R., Knuefermann, P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649709/ https://www.ncbi.nlm.nih.gov/pubmed/23690658 http://dx.doi.org/10.1155/2013/217297

Ejemplares similares

Synthetic CpG oligonucleotides induce a genetic profile ameliorating murine myocardial I/R injury
por: Hilbert, Tobias, et al.
Publicado: (2018)

Pre-conditioning with synthetic CpG-oligonucleotides attenuates myocardial ischemia/reperfusion injury via IL-10 up-regulation
por: Markowski, P., et al.
Publicado: (2013)

CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo
por: Knuefermann, Pascal, et al.
Publicado: (2007)

Vascular Dysfunction following Polymicrobial Sepsis: Role of Pattern Recognition Receptors
por: Ehrentraut, Stefan Felix, et al.
Publicado: (2012)

Synthetic Human TLR9-LRR11 Peptide Attenuates TLR9 Signaling by Binding to and thus Decreasing Internalization of CpG Oligodeoxynucleotides
por: Pan, Xichun, et al.
Publicado: (2016)

TLR2 stimulation induces cardiac inflammation but not cardiac depression in vivo
por: Boehm, Olaf, et al.
Publicado: (2013)

Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis
por: Lohner, Ralph, et al.
Publicado: (2013)

TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA
por: Chockalingam, Annapoorani, et al.
Publicado: (2008)

Development of CpG-Oligodeoxynucleotides for Effective Activation of Rabbit TLR9 Mediated Immune Responses
por: Chuang, Tsung-Hsien, et al.
Publicado: (2014)

Immunotherapy of Malignant Glioma by Noninvasive Administration of TLR9 Agonist CpG Nano‐Immunoadjuvant
por: Wei, Jingjing, et al.
Publicado: (2022)

Systemically Administered Ligands of Toll-Like Receptor 2, -4, and -9 Induce Distinct Inflammatory Responses in the Murine Lung
por: Ehrentraut, H., et al.
Publicado: (2011)

Three-Dimensional Modeling of CpG DNA Binding with Matrix Lumican Shows Leucine-Rich Repeat Motif Involvement as in TLR9-CpG DNA Interactions
por: Choi, Tansol, et al.
Publicado: (2023)

3D modeling of CpG DNA binding with matrix lumican shows leucine-rich repeat motif involvement as in TLR9-CpG DNA interactions
por: Choi, Tansol, et al.
Publicado: (2023)

TLR9-mediated ARF6 activation is involved in advancing CpG ODN cellular uptake
por: Wu, Jing-Yiing, et al.
Publicado: (2012)

Route of Administration of the TLR9 Agonist CpG Critically Determines the Efficacy of Cancer Immunotherapy in Mice
por: Nierkens, Stefan, et al.
Publicado: (2009)

CpG oligonucleotides bind TLR9 and RRM-Containing proteins in Atlantic Salmon (Salmo salar)
por: Iliev, Dimitar B, et al.
Publicado: (2013)

The Effect of TLR9 Agonist CpG Oligodeoxynucleotides on the Intestinal Immune Response of Cobia (Rachycentron canadum)
por: Byadgi, Omkar, et al.
Publicado: (2014)

PIKfyve Regulates the Endosomal Localization of CpG Oligodeoxynucleotides to Elicit TLR9-Dependent Cellular Responses
por: Hazeki, Kaoru, et al.
Publicado: (2013)

pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG
por: Wu, Jing, et al.
Publicado: (2019)

CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion
por: Sanjuan, Miguel A., et al.
Publicado: (2006)

Activation of CpG-ODN-Induced TLR9 Signaling Inhibited by Interleukin-37 in U937 Human Macrophages
por: Kim, Seong-Kyu, et al.
Publicado: (2021)

CpG-oligodeoxynucleotides developed for grouper toll-like receptor (TLR) 21s effectively activate mouse and human TLR9s mediated immune responses
por: Yeh, Da-Wei, et al.
Publicado: (2017)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation
por: Liu, Wancheng, et al.
Publicado: (2017)

A Naturally Occurring Variant in Human TLR9, P99L, Is Associated with Loss of CpG Oligonucleotide Responsiveness
por: Kubarenko, Andriy V., et al.
Publicado: (2010)

TLR9 Ligand (CpG Oligodeoxynucleotide) Induces CLL B-Cells to Differentiate into CD20(+) Antibody-Secreting Cells
por: Ghamlouch, Hussein, et al.
Publicado: (2014)

Involvement of DNA-PKcs in the Type I IFN Response to CpG-ODNs in Conventional Dendritic Cells in TLR9-Dependent or -Independent Manners
por: Ma, Chi, et al.
Publicado: (2015)

Suppressive CpG
por: Van Epps, Heather L.
Publicado: (2005)

The effect of the TLR9 ligand CpG-oligodeoxynucleotide on the protective immune response to alcelaphine herpesvirus-1-mediated malignant catarrhal fever in cattle
por: Parameswaran, Nevi, et al.
Publicado: (2014)

Factors to preserve CpG-rich sequences in methylated CpG islands
por: Miyahara, Hiroki, et al.
Publicado: (2015)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
por: Arand, Julia, et al.
Publicado: (2012)

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
por: Jang, Hyun Sik, et al.
Publicado: (2017)

Beta(2)-Adrenoceptor Stimulation Suppresses TLR9-Dependent IFNA1 Secretion in Human Peripheral Blood Mononuclear Cells
por: Hilbert, Tobias, et al.
Publicado: (2013)

Dual effects of a CpG-DNAzyme targeting mutant EGFR transcripts in lung cancer cells: TLR9 activation and EGFR downregulation
por: Jang, Dahye, et al.
Publicado: (2018)

The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8(+) T-cell responses in vitro
por: Papagno, Laura, et al.
Publicado: (2020)

Prediction of CpG-island function: CpG clustering vs. sliding-window methods
por: Hackenberg, Michael, et al.
Publicado: (2010)

CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands
por: Oshikawa, Daiki, et al.
Publicado: (2022)

Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α
por: Manoharan, Yuvaraj, et al.
Publicado: (2012)

CpGIF: an algorithm for the identification of CpG islands
por: Sujuan, Ye, et al.
Publicado: (2008)

The Effects of O(6)-methyl Guanine DNA-methyl Transferase Promotor Methylation and CpG1, CpG2, CpG3 and CpG4 Methylation on Treatment Response and their Prognostic Significance in Patients with Glioblastoma
por: Yildiz, OG, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_oqes82n365bb1m1bhu5n4rphl7