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Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage

Delayed cerebral vasospasm is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). While the cellular mechanisms underlying vasospasm remain unclear, it is believed that inflammation may play a critical role in vasospasm. Matrix metalloproteinasees (MMPs...

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Detalles Bibliográficos
Autores principales: Mehta, Vivek, Russin, Jonathan, Spirtos, Alexandra, He, Shuhan, Adamczyk, Peter, Amar, Arun P., Mack, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649803/
https://www.ncbi.nlm.nih.gov/pubmed/23691315
http://dx.doi.org/10.1155/2013/943761
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author Mehta, Vivek
Russin, Jonathan
Spirtos, Alexandra
He, Shuhan
Adamczyk, Peter
Amar, Arun P.
Mack, William J.
author_facet Mehta, Vivek
Russin, Jonathan
Spirtos, Alexandra
He, Shuhan
Adamczyk, Peter
Amar, Arun P.
Mack, William J.
author_sort Mehta, Vivek
collection PubMed
description Delayed cerebral vasospasm is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). While the cellular mechanisms underlying vasospasm remain unclear, it is believed that inflammation may play a critical role in vasospasm. Matrix metalloproteinasees (MMPs) are a family of extracellular and membrane-bound proteases capable of degrading the blood-rain barrier (BBB). As such, MMP upregulation following SAH may result in a proinflammatory extravascular environment capable of inciting delayed cerebral vasospasm. This paper presents an overview of MMPs and describes existing data pertinent to delayed cerebral vasospasm.
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spelling pubmed-36498032013-05-20 Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage Mehta, Vivek Russin, Jonathan Spirtos, Alexandra He, Shuhan Adamczyk, Peter Amar, Arun P. Mack, William J. Neurol Res Int Review Article Delayed cerebral vasospasm is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). While the cellular mechanisms underlying vasospasm remain unclear, it is believed that inflammation may play a critical role in vasospasm. Matrix metalloproteinasees (MMPs) are a family of extracellular and membrane-bound proteases capable of degrading the blood-rain barrier (BBB). As such, MMP upregulation following SAH may result in a proinflammatory extravascular environment capable of inciting delayed cerebral vasospasm. This paper presents an overview of MMPs and describes existing data pertinent to delayed cerebral vasospasm. Hindawi Publishing Corporation 2013 2013-04-03 /pmc/articles/PMC3649803/ /pubmed/23691315 http://dx.doi.org/10.1155/2013/943761 Text en Copyright © 2013 Vivek Mehta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mehta, Vivek
Russin, Jonathan
Spirtos, Alexandra
He, Shuhan
Adamczyk, Peter
Amar, Arun P.
Mack, William J.
Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage
title Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage
title_full Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage
title_fullStr Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage
title_full_unstemmed Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage
title_short Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage
title_sort matrix metalloproteinases in cerebral vasospasm following aneurysmal subarachnoid hemorrhage
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649803/
https://www.ncbi.nlm.nih.gov/pubmed/23691315
http://dx.doi.org/10.1155/2013/943761
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