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Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage
Delayed cerebral vasospasm is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). While the cellular mechanisms underlying vasospasm remain unclear, it is believed that inflammation may play a critical role in vasospasm. Matrix metalloproteinasees (MMPs...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649803/ https://www.ncbi.nlm.nih.gov/pubmed/23691315 http://dx.doi.org/10.1155/2013/943761 |
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author | Mehta, Vivek Russin, Jonathan Spirtos, Alexandra He, Shuhan Adamczyk, Peter Amar, Arun P. Mack, William J. |
author_facet | Mehta, Vivek Russin, Jonathan Spirtos, Alexandra He, Shuhan Adamczyk, Peter Amar, Arun P. Mack, William J. |
author_sort | Mehta, Vivek |
collection | PubMed |
description | Delayed cerebral vasospasm is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). While the cellular mechanisms underlying vasospasm remain unclear, it is believed that inflammation may play a critical role in vasospasm. Matrix metalloproteinasees (MMPs) are a family of extracellular and membrane-bound proteases capable of degrading the blood-rain barrier (BBB). As such, MMP upregulation following SAH may result in a proinflammatory extravascular environment capable of inciting delayed cerebral vasospasm. This paper presents an overview of MMPs and describes existing data pertinent to delayed cerebral vasospasm. |
format | Online Article Text |
id | pubmed-3649803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36498032013-05-20 Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage Mehta, Vivek Russin, Jonathan Spirtos, Alexandra He, Shuhan Adamczyk, Peter Amar, Arun P. Mack, William J. Neurol Res Int Review Article Delayed cerebral vasospasm is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). While the cellular mechanisms underlying vasospasm remain unclear, it is believed that inflammation may play a critical role in vasospasm. Matrix metalloproteinasees (MMPs) are a family of extracellular and membrane-bound proteases capable of degrading the blood-rain barrier (BBB). As such, MMP upregulation following SAH may result in a proinflammatory extravascular environment capable of inciting delayed cerebral vasospasm. This paper presents an overview of MMPs and describes existing data pertinent to delayed cerebral vasospasm. Hindawi Publishing Corporation 2013 2013-04-03 /pmc/articles/PMC3649803/ /pubmed/23691315 http://dx.doi.org/10.1155/2013/943761 Text en Copyright © 2013 Vivek Mehta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mehta, Vivek Russin, Jonathan Spirtos, Alexandra He, Shuhan Adamczyk, Peter Amar, Arun P. Mack, William J. Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage |
title | Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage |
title_full | Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage |
title_fullStr | Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage |
title_full_unstemmed | Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage |
title_short | Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage |
title_sort | matrix metalloproteinases in cerebral vasospasm following aneurysmal subarachnoid hemorrhage |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649803/ https://www.ncbi.nlm.nih.gov/pubmed/23691315 http://dx.doi.org/10.1155/2013/943761 |
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