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T cell memory to evolutionarily conserved and shared hemagglutinin epitopes of H1N1 viruses: a pilot scale study

BACKGROUND: The 2009 pandemic influenza was milder than expected. Based on the apparent lack of pre-existing cross-protective antibodies to the A (H1N1)pdm09 strain, it was hypothesized that pre-existing CD4+ T cellular immunity provided the crucial immunity that led to an attenuation of disease sev...

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Detalles Bibliográficos
Autores principales: Duvvuri, Venkata R, Duvvuri, Bhargavi, Jamnik, Veronica, Gubbay, Jonathan B, Wu, Jianhong, Wu, Gillian E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649888/
https://www.ncbi.nlm.nih.gov/pubmed/23641949
http://dx.doi.org/10.1186/1471-2334-13-204