Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?

Vitamin B12 is an essential micronutrient required for optimal hemopoetic, neuro-cognitive and cardiovascular function. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus. It presents with diverse clini...

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Detalles Bibliográficos
Autores principales: Kibirige, Davis, Mwebaze, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649932/
https://www.ncbi.nlm.nih.gov/pubmed/23651730
http://dx.doi.org/10.1186/2251-6581-12-17
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author Kibirige, Davis
Mwebaze, Raymond
author_facet Kibirige, Davis
Mwebaze, Raymond
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description Vitamin B12 is an essential micronutrient required for optimal hemopoetic, neuro-cognitive and cardiovascular function. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus. It presents with diverse clinical manifestations ranging from impaired memory, dementia, delirium, peripheral neuropathy, sub acute combined degeneration of the spinal cord, megaloblastic anemia and pancytopenia. This review article offers a current perspective on the physiological roles of vitamin B12, proposed pathophysiological mechanisms of vitamin B12 deficiency, screening for vitamin B12 deficiency and vitamin B12 supplementation among patients with diabetes mellitus.
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spelling pubmed-36499322013-05-10 Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? Kibirige, Davis Mwebaze, Raymond J Diabetes Metab Disord Review Article Vitamin B12 is an essential micronutrient required for optimal hemopoetic, neuro-cognitive and cardiovascular function. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus. It presents with diverse clinical manifestations ranging from impaired memory, dementia, delirium, peripheral neuropathy, sub acute combined degeneration of the spinal cord, megaloblastic anemia and pancytopenia. This review article offers a current perspective on the physiological roles of vitamin B12, proposed pathophysiological mechanisms of vitamin B12 deficiency, screening for vitamin B12 deficiency and vitamin B12 supplementation among patients with diabetes mellitus. Springer 2013-05-07 /pmc/articles/PMC3649932/ /pubmed/23651730 http://dx.doi.org/10.1186/2251-6581-12-17 Text en Copyright © 2013 Kibirige and Mwebaze; licensee BioMed Central Ltd. https://creativecommons.org/licenses/by/2.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0 (https://creativecommons.org/licenses/by/2.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kibirige, Davis
Mwebaze, Raymond
Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
title Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
title_full Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
title_fullStr Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
title_full_unstemmed Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
title_short Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
title_sort vitamin b12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649932/
https://www.ncbi.nlm.nih.gov/pubmed/23651730
http://dx.doi.org/10.1186/2251-6581-12-17
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