IRES-driven Expression of the Capsid Protein of the Venezuelan Equine Encephalitis Virus TC-83 Vaccine Strain Increases Its Attenuation and Safety

The live-attenuated TC-83 strain is the only licensed veterinary vaccine available to protect equids against Venezuelan equine encephalitis virus (VEEV) and to protect humans indirectly by preventing equine amplification. However, TC-83 is reactogenic due to its reliance on only two attenuating poin...

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Detalles Bibliográficos
Autores principales: Guerbois, Mathilde, Volkova, Eugenia, Forrester, Naomi L., Rossi, Shannan L., Frolov, Ilya, Weaver, Scott C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649961/
https://www.ncbi.nlm.nih.gov/pubmed/23675542
http://dx.doi.org/10.1371/journal.pntd.0002197

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