Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore

Several live attenuated rotavirus (RV) vaccines have been licensed, but the mechanisms of protective immunity are still poorly understood. The most frequent human B cell response is directed to the internal protein VP6 on the surface of double-layered particles, which is normally exposed only in the...

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Detalles Bibliográficos
Autores principales: Aiyegbo, Mohammed S., Sapparapu, Gopal, Spiller, Benjamin W., Eli, Ilyas M., Williams, Dewight R., Kim, Robert, Lee, David E., Liu, Tong, Li, Sheng, Woods, Virgil L., Nannemann, David P., Meiler, Jens, Stewart, Phoebe L., Crowe, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650007/
https://www.ncbi.nlm.nih.gov/pubmed/23671563
http://dx.doi.org/10.1371/journal.pone.0061101

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