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A Novel Fully Automated Molecular Diagnostic System (AMDS) for Colorectal Cancer Mutation Detection

BACKGROUND: KRAS, BRAF and PIK3CA mutations are frequently observed in colorectal cancer (CRC). In particular, KRAS mutations are strong predictors for clinical outcomes of EGFR-targeted treatments such as cetuximab and panitumumab in metastatic colorectal cancer (mCRC). For mutation analysis, the c...

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Detalles Bibliográficos
Autores principales:	Kitano, Shiro, Myers, Jamie, Nakamura, Junko, Yamane, Akio, Yamashita, Mami, Nakayama, Masato, Tsukahara, Yusuke, Ushida, Hiroshi, Liu, Wanqing, Ratain, Mark J., Amano, Masahiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650034/ https://www.ncbi.nlm.nih.gov/pubmed/23671647 http://dx.doi.org/10.1371/journal.pone.0062989

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