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LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA

The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I interferons (IFNs). Laboratory of genetics and...

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Detalles Bibliográficos
Autores principales:	Childs, Kay S., Randall, Richard E., Goodbourn, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650065/ https://www.ncbi.nlm.nih.gov/pubmed/23671710 http://dx.doi.org/10.1371/journal.pone.0064202

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