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A Novel Adenoviral Hybrid-vector System Carrying a Plasmid Replicon for Safe and Efficient Cell and Gene Therapeutic Applications

In dividing cells, the two aims a gene therapeutic approach should accomplish are efficient nuclear delivery and retention of therapeutic DNA. For stable transgene expression, therapeutic DNA can either be maintained by somatic integration or episomal persistence of which the latter approach would d...

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Detalles Bibliográficos
Autores principales:	Voigtlander, Richard, Haase, Rudolf, Mück-Hausl, Martin, Zhang, Wenli, Boehme, Philip, Lipps, Hans-Joachim, Schulz, Eric, Baiker, Armin, Ehrhardt, Anja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Methods - Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650243/ https://www.ncbi.nlm.nih.gov/pubmed/23549553 http://dx.doi.org/10.1038/mtna.2013.11

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