A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase

Telomerase comprises a reverse transcriptase and an internal RNA template that maintains telomeres in many eukaryotes, and it is a well-validated cancer target. However, there is a dearth of small molecules with efficacy against human telomerase in vivo. We developed a surrogate yeast high-throughpu...

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Detalles Bibliográficos
Autores principales: Wong, Lai Hong, Unciti-Broceta, Asier, Spitzer, Michaela, White, Rachel, Tyers, Mike, Harrington, Lea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650558/
https://www.ncbi.nlm.nih.gov/pubmed/23521791
http://dx.doi.org/10.1016/j.chembiol.2012.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650558/
https://www.ncbi.nlm.nih.gov/pubmed/23521791
http://dx.doi.org/10.1016/j.chembiol.2012.12.008

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