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A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase
Telomerase comprises a reverse transcriptase and an internal RNA template that maintains telomeres in many eukaryotes, and it is a well-validated cancer target. However, there is a dearth of small molecules with efficacy against human telomerase in vivo. We developed a surrogate yeast high-throughpu...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650558/ https://www.ncbi.nlm.nih.gov/pubmed/23521791 http://dx.doi.org/10.1016/j.chembiol.2012.12.008 |