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Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment

The inherently toxic nature of chemotherapy drugs is essential for them to kill cancer cells but is also the source of the detrimental side effects experienced by patients. One strategy to reduce these side effects is to limit the healthy tissue exposure by encapsulating the drugs in a vehicle that...

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Autores principales: Ibsen, Stuart, Schutt, Carolyn E, Esener, Sadik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650568/
https://www.ncbi.nlm.nih.gov/pubmed/23667309
http://dx.doi.org/10.2147/DDDT.S31564
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author Ibsen, Stuart
Schutt, Carolyn E
Esener, Sadik
author_facet Ibsen, Stuart
Schutt, Carolyn E
Esener, Sadik
author_sort Ibsen, Stuart
collection PubMed
description The inherently toxic nature of chemotherapy drugs is essential for them to kill cancer cells but is also the source of the detrimental side effects experienced by patients. One strategy to reduce these side effects is to limit the healthy tissue exposure by encapsulating the drugs in a vehicle that demonstrates a very low leak rate in circulation while simultaneously having the potential for rapid release once inside the tumor. Designing a vehicle with these two opposing properties is the major challenge in the field of drug delivery. A triggering event is required to change the vehicle from its stable circulating state to its unstable release state. A unique mechanical actuation type trigger is possible by harnessing the size changes that occur when microbubbles interact with ultrasound. These mechanical actuations can burst liposomes and cell membranes alike allowing for rapid drug release and facilitating delivery into nearby cells. The tight focusing ability of the ultrasound to just a few cubic millimeters allows for precise control over the tissue location where the microbubbles destabilize the vehicles. This allows the ultrasound to highlight the tumor tissue and cause rapid drug release from any carrier present. Different vehicle designs have been demonstrated from carrying drug on just the surface of the microbubble itself to encapsulating the microbubble along with the drug within a liposome. In the future, nanoparticles may extend the circulation half-life of these ultrasound triggerable drug-delivery vehicles by acting as nucleation sites of ultrasound-induced mechanical actuation. In addition to the drug delivery capability, the microbubble size changes can also be used to create imaging contrast agents that could allow the internal chemical environment of a tumor to be studied to help improve the diagnosis and detection of cancer. The ability to attain truly tumor-specific release from circulating drug-delivery vehicles is an exciting future prospect to reduce chemotherapy side effects while increasing drug effectiveness.
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spelling pubmed-36505682013-05-10 Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment Ibsen, Stuart Schutt, Carolyn E Esener, Sadik Drug Des Devel Ther Review The inherently toxic nature of chemotherapy drugs is essential for them to kill cancer cells but is also the source of the detrimental side effects experienced by patients. One strategy to reduce these side effects is to limit the healthy tissue exposure by encapsulating the drugs in a vehicle that demonstrates a very low leak rate in circulation while simultaneously having the potential for rapid release once inside the tumor. Designing a vehicle with these two opposing properties is the major challenge in the field of drug delivery. A triggering event is required to change the vehicle from its stable circulating state to its unstable release state. A unique mechanical actuation type trigger is possible by harnessing the size changes that occur when microbubbles interact with ultrasound. These mechanical actuations can burst liposomes and cell membranes alike allowing for rapid drug release and facilitating delivery into nearby cells. The tight focusing ability of the ultrasound to just a few cubic millimeters allows for precise control over the tissue location where the microbubbles destabilize the vehicles. This allows the ultrasound to highlight the tumor tissue and cause rapid drug release from any carrier present. Different vehicle designs have been demonstrated from carrying drug on just the surface of the microbubble itself to encapsulating the microbubble along with the drug within a liposome. In the future, nanoparticles may extend the circulation half-life of these ultrasound triggerable drug-delivery vehicles by acting as nucleation sites of ultrasound-induced mechanical actuation. In addition to the drug delivery capability, the microbubble size changes can also be used to create imaging contrast agents that could allow the internal chemical environment of a tumor to be studied to help improve the diagnosis and detection of cancer. The ability to attain truly tumor-specific release from circulating drug-delivery vehicles is an exciting future prospect to reduce chemotherapy side effects while increasing drug effectiveness. Dove Medical Press 2013-05-03 /pmc/articles/PMC3650568/ /pubmed/23667309 http://dx.doi.org/10.2147/DDDT.S31564 Text en © 2013 Ibsen et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Ibsen, Stuart
Schutt, Carolyn E
Esener, Sadik
Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment
title Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment
title_full Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment
title_fullStr Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment
title_full_unstemmed Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment
title_short Microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment
title_sort microbubble-mediated ultrasound therapy: a review of its potential in cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650568/
https://www.ncbi.nlm.nih.gov/pubmed/23667309
http://dx.doi.org/10.2147/DDDT.S31564
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