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Halting the Allergic March
The prevalence of childhood allergic diseases, such as allergic asthma, allergic rhinitis, and atopic dermatitis, has increased exponentially. In Singapore, the prevalence of asthma at all ages exceeds 20%, and around 50% of Singaporean children show features of an underlying allergy. The exact envi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
World Allergy Organization
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650954/ https://www.ncbi.nlm.nih.gov/pubmed/23283392 http://dx.doi.org/10.1097/WOX.0b013e31816ddbc1 |
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author | Van Bever, Hugo P Samuel, Sudesh T Lee, Bee Wah |
author_facet | Van Bever, Hugo P Samuel, Sudesh T Lee, Bee Wah |
author_sort | Van Bever, Hugo P |
collection | PubMed |
description | The prevalence of childhood allergic diseases, such as allergic asthma, allergic rhinitis, and atopic dermatitis, has increased exponentially. In Singapore, the prevalence of asthma at all ages exceeds 20%, and around 50% of Singaporean children show features of an underlying allergy. The exact environmental causes for the increase of allergic diseases have not yet been identified, but most researchers agree that a decreased bacterial load in young children may be one of the reasons for the increase. However, the causes of allergy are multiple, and the development of an allergic disease is the result of complex interactions between genetic constitution and environmental factors. In this review article, different aspects of allergic sensitization are covered, including prenatal and postnatal sensitization. The phenomenon of the "allergic march" (switching from one clinical expression of allergy to another) and its underlying mechanisms are discussed. The last part of this review article is on prevention and treatment of allergic diseases, including the role of bacterial products (probiotics, prebiotics, and synbiotics) and the role of immunotherapy, including sublingual immunotherapy. |
format | Online Article Text |
id | pubmed-3650954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | World Allergy Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-36509542013-07-12 Halting the Allergic March Van Bever, Hugo P Samuel, Sudesh T Lee, Bee Wah World Allergy Organ J Review Article The prevalence of childhood allergic diseases, such as allergic asthma, allergic rhinitis, and atopic dermatitis, has increased exponentially. In Singapore, the prevalence of asthma at all ages exceeds 20%, and around 50% of Singaporean children show features of an underlying allergy. The exact environmental causes for the increase of allergic diseases have not yet been identified, but most researchers agree that a decreased bacterial load in young children may be one of the reasons for the increase. However, the causes of allergy are multiple, and the development of an allergic disease is the result of complex interactions between genetic constitution and environmental factors. In this review article, different aspects of allergic sensitization are covered, including prenatal and postnatal sensitization. The phenomenon of the "allergic march" (switching from one clinical expression of allergy to another) and its underlying mechanisms are discussed. The last part of this review article is on prevention and treatment of allergic diseases, including the role of bacterial products (probiotics, prebiotics, and synbiotics) and the role of immunotherapy, including sublingual immunotherapy. World Allergy Organization 2008-04-15 /pmc/articles/PMC3650954/ /pubmed/23283392 http://dx.doi.org/10.1097/WOX.0b013e31816ddbc1 Text en Copyright ©2008 World Allergy Organization; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Van Bever, Hugo P Samuel, Sudesh T Lee, Bee Wah Halting the Allergic March |
title | Halting the Allergic March |
title_full | Halting the Allergic March |
title_fullStr | Halting the Allergic March |
title_full_unstemmed | Halting the Allergic March |
title_short | Halting the Allergic March |
title_sort | halting the allergic march |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650954/ https://www.ncbi.nlm.nih.gov/pubmed/23283392 http://dx.doi.org/10.1097/WOX.0b013e31816ddbc1 |
work_keys_str_mv | AT vanbeverhugop haltingtheallergicmarch AT samuelsudesht haltingtheallergicmarch AT leebeewah haltingtheallergicmarch |