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Clinical Efficacy and Safety of a Combined Loratadine-Betamethasone Oral Solution in the Treatment of Severe Pediatric Perennial Allergic Rhinitis

BACKGROUND: Allergic rhinitis is a highly prevalent condition, particularly among children, whose schoolwork and quality of life may be impaired by its symptoms. METHODS: In this prospective, multicenter study, children between 6 and 12 years old with a diagnosis of severe perennial allergic rhiniti...

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Detalles Bibliográficos
Autores principales: de Morales, Teolinda Mendoza, Sánchez, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Allergy Organization 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651010/
https://www.ncbi.nlm.nih.gov/pubmed/23282980
http://dx.doi.org/10.1097/WOX.0b013e31819f2105
Descripción
Sumario:BACKGROUND: Allergic rhinitis is a highly prevalent condition, particularly among children, whose schoolwork and quality of life may be impaired by its symptoms. METHODS: In this prospective, multicenter study, children between 6 and 12 years old with a diagnosis of severe perennial allergic rhinitis received a combination of the nonsedating antihistamine loratadine and the corticosteroid betamethasone in an oral solution for 5 days. RESULTS: The total nasal and ocular symptom score was significantly reduced from 11.4 (± 2.1) before treatment to 2.9 (± 2.4) after treatment (P < 0.01). Significant reductions (P < 0.01) were also observed for sneezing, nasal pruritus, nasal congestion, rhinorrhea, postnasal drip, and ocular erythema and pruritus. No adverse events were reported, and no subject discontinued treatment. CONCLUSIONS: The combination of loratadine and betamethasone in an oral solution was safe and effective as initial short-term treatment for symptoms of severe perennial allergic rhinitis in school-aged children.