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Senescent Fibroblasts Enhance Early Skin Carcinogenic Events via a Paracrine MMP-PAR-1 Axis

The incidence of carcinoma increases greatly with aging, but the cellular and molecular mechanisms underlying this correlation are only partly known. It is established that senescent fibroblasts promote the malignant progression of already-transformed cells through secretion of inflammatory mediator...

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Detalles Bibliográficos
Autores principales:	Malaquin, Nicolas, Vercamer, Chantal, Bouali, Fatima, Martien, Sébastien, Deruy, Emeric, Wernert, Nicolas, Chwastyniak, Maggy, Pinet, Florence, Abbadie, Corinne, Pourtier, Albin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651095/ https://www.ncbi.nlm.nih.gov/pubmed/23675494 http://dx.doi.org/10.1371/journal.pone.0063607

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